Recent experiments in our laboratory have revealed a genetic correlation of the sensitivity of inbred mouse strains to different assays of nociception using noxious heat stimuli. An open question is whether the property of the noxious stimulus underlying the genetic correlation is heat specifically or simply a temperature (hot or cold) in the noxious range. The existing electrophysiological, ps...

We provide an econometric analysis for the factor models when the latent factors can be explained partially by several observed explanatory proxies. In financial factor models for instance, the unknown factors can be reasonably well predicted by a few observable proxies, such as the Fama-French factors. In diffusion index forecasts, identified factors are strongly related to several directly me...

In the paper, we suggest three tests on the validity of a factor model which can be applied for both, small-dimensional and large-dimensional data. The exact and asymptotic distributions of the resulting test statistics are derived under classical and highdimensional asymptotic regimes. It is shown that the critical values of the proposed tests can be calibrated empirically by generating a samp...

We propose a new methodology for the Bayesian analysis of nonlinear nonGaussian state space models with a Gaussian time-varying signal, where the signal is a function of a possibly high-dimensional state vector. The novelty of our approach is the development of proposal densities for the joint posterior density of parameter and state vectors: a mixture of Student’s t-densities as the marginal p...

Agrobacterium tumefaciens wild-type strains have a unique quorum-sensing (QS)-dependent Ti plasmid conjugative transfer phenotype in which QS signaling is activated by corresponding conjugative opine inducers. Strain K588, with a nopaline-type chromosomal background harboring an octopine-type Ti plasmid, however, is a spontaneous mutant displaying a constitutive phenotype in QS. In this study, ...

Agrobacterium tumefaciens induces crown gall tumors by transferring a piece of its tumor-inducing plasmid into plant cells. This transferred DNA encodes the synthesis of indole acetic acid (IAA) and cytokinin, and their overproduction results in tumor formation. The transfer is initiated by a two-component regulatory system, VirA/G recognizing plant signal molecules in the plant rhizosphere and...