A rare case of ovarian sarcoidosis with peritoneal and omental involvement presenting as an ovarian malignancy is presented. Clinical, laboratory, and radiological evaluation of the patient revealed ascites and high levels of serum CA 125 and CA 15.3. The diagnosis of sarcoidosis was confirmed with pathology findings on tissues obtained during surgical laparotomy. Establishing the diagnosis of ...

BACKGROUND Recent studies have proposed the measurement of CA 19-9 and IL-6 as an alternative to CA 125 as markers for endometriosis. This study was performed in order to verify the clinical value of serum CA 125, CA 19-9 and IL-6 levels, either by themselves or combined, in the detection of the disease. METHODS In a prospective cohort study, serum concentrations of CA 125, CA 19-9 and IL-6 w...

An elevated serum CA125 level in association with a pelvic mass, pleural effusion, and massive ascites usually signifies a dismal prognosis in a postmenopausal woman. However, surgery and histopathological examination are required for the correct diagnosis and treatment, since an elevated CA125 level can be falsely positive for ovarian malignancy. We present a case of Meigs' syndrome due to rig...

OBJECTIVE We aimed to determine the ideal cut-off of nadir serum CA-125 level for prediction of progression free survival. METHODS Among 267 patients who achieved complete remission after chemotherapy, the correlation between nadir CA-125 and progression free survival were compared among the subgroups classified according to the distribution of CA-125. The diagnostic odds ratio and area under...

BACKGROUND The aim of this study was to evaluate the combination of serum CA125 and Transvaginal Ultra Sonography (TVUS) score, as a screening procedure for ovarian cancer in premenopausal and postmenopausal women. PATIENTS AND METHODS A retrospective case-control pilot study was conducted. The files of 120 women with ovarian neoplasia detected by TVUS and increased CA125 level, within the fr...

Paratesticular cystadenocarcinoma is a rare form of ovarian epithelial tumor, with less than forty cases reported to date.1 Clinical presentation is scrotal enlargement with no significant pain.2 Ultrasound often shows a hypoechoic vascularized mass, with variable amounts of hydrocele. CT and MRI are not able to differentiate this tumor from other differential diagnosis. When normal values of h...

Gordon J. S. Rustin, Robert C. Bast, Jr., Gary J. Kelloff, J. Carl Barrett, Stephen K. Carter, Perry D. Nisen, Caroline C. Sigman, David R. Parkinson, and Raymond W. Ruddon Department of Medical Oncology, Mount Vernon Cancer Centre, Northwood, Middlesex, United Kingdom; Department of Translational Research, University of Texas M. D. Anderson Cancer Center, Houston, Texas; Division of Cancer Tre...

Over more than a decade of clinical use, CA-125 has proven itself to be one of the most useful tumor markers in cancer medicine. The major clinical utility of this serum marker is in following the clinical course of women with known ovarian cancer. Other potential uses of CA-125 include the evaluation of the effectiveness of new antineoplastic agents in this malignancy, and in the modification ...

BACKGROUND This researcher previously found that serum levels of some inflammatory cytokines are elevated in patients with cardiovascular disease (CVD). Hence, this study investigated the relationship between circulating levels of pro-anti-inflammatory cytokines, T-cell activation marker and carbohydrate antigen 125 (CA 125) for the first time in obese Egyptian patients with heart failure (HF)....

PURPOSE Previous studies have shown that elevated preoperative serum CA 125 levels strongly correlate with various clinical and pathological variables and prognosis of patients with endometrial carcinoma (EC). The aim of the present study was to evaluate the clinical significance of preoperative serum CA 125 levels in patients with EC. METHODS A retrospective study of all EC patients treated ...