Chia (Salvia sp) seeds were investtgated as a source of natural lipid antioxidants. Methanolic and aqueous extracts of defatted chia seeds possessed potent antioxidant activity. Analysis of 2 batches of cbia-seed oils demonstrated marked difference in the fatty acid composition of the oils, In both batches, the oils had high concentrations of polyunsauarated fatty acids. The major antioxidant a...

In this study, three type II phenolic acids (caffeic acid, p-hydroxycinnamic acid, and ferulic acid) were used to synthesize a total of 18 phenolic acid derivatives. With molecular docking for molecule design and target protein (factors) screening, in combination with the confirmation of target proteins (factors) by surface plasmon resonance, and the evaluation of haemostatic and anticoagulant ...

BACKGROUND 5-lipoxygenase (5-LO) catalyses the transformation of arachidonic acid (AA) into leukotrienes (LTs), which are important lipid mediators of inflammation. LTs have been directly implicated in inflammatory diseases like asthma, atherosclerosis and rheumatoid arthritis; therefore inhibition of LT biosynthesis is a strategy for the treatment of these chronic diseases. METHODOLOGY/PRINC...

product containing a catechol group with an a ,b-unsaturated carboxylic acid chain (Fig. 1), is a widespread phenolic acid, naturally found in many agricultural products such as fruits, vegetables, wine, olive oil, and coffee. Caffeic acid has been reported to possess a wide spectrum of biological effects such as antioxidant activity, inhibition of enzyme activities (lipoxygenase, glutathione S...

This study aimed to determine individual phenolic compounds of common produced Turkish raisins. As material, Sultan 7, Antep Karasi and Razaki raisins were used. The HPLC method was performed for the analysis 11 compounds. major acid trans-caftaric flavan-3-ol also (+)-catechin. varied between 21.56 46.84 µg/g in samples (+)-catechin 2.21 74.12 µg/g. Caffeic second most abundant with 11.06-21.5...

Objective(s): Precision-cut tissue slices are considered an organotypic 3D model widely used in biomedical research. The comet assay is an important screening test for early genotoxicity risk assessment that is mainly applied on in vitro models.  The aim of the present study was to provide a 3D organ system for determination of genotoxicity using a modified method of the comet assay since the s...

A novel acyltransferase from cotyledons of tomato (Lycopersicon esculentum Mill.), which catalyzes the transfer of caffeic acid from chlorogenic acid (5-O-caffeoylquinic acid) to glucaric and galactaric acids, was purified with a 2400-fold enrichment and a 4% recovery. The enzyme showed specific activities (theoretical V(max) per milligram of protein) of 625 nanokatals (caffeoylglucaric acid fo...

BACKGROUND: Caffeic acid has been reported to activate caspases in MG-63 osteosarcoma cells, which can lead apoptosis via both extrinsic and intrinsic apoptotic pathways. Translocation of protein kinase C delta (PKCδ), reduces mitochondrial membrane potential (ΔΨm), is involved apoptosis. The role PKCδ translocation ΔΨm alteration caffeic acid-induced cell are largely unknown. Present study inv...

In an effort to evaluate the antioxidative property in mango, a laboratory study was conducted at BCKV, Mohanpur during 2019 with ten varieties of mango selected on basis popularity and area coverage. The pulp fruit samples harvested firm ripe stage showed wide genotypic variability contents antioxidants activity enzymes tested. Ascorbic acid total phenol ranged from 16.20 44.26 mg 100 g-1 (aro...

PURPOSE The paper tried to systematically investigate the in vitro antioxidant activity of Rhizoma Cibotii (RC) for the first time. METHOD The methanol extract from RC (MERC) was prepared then systematically investigated by various antioxidant assays, including: DPPH• (1, 1-diphenyl-2-picrylhydrazyl radical), ABTS•(+) (3-ethylbenzthiazoline-6- sulfonic acid diammonium salt radical), •O2- (sup...