Since Neuhauser (I1944) drew attention to the radiological features of intra-abdominal calcification associated with meconium peritonitis, this condition has been diagnosed with increasing frequency. However, all cases showing intra-abdominal calcification at birth are not due to meconium peritonitis. Up to the present time four cases have been reported which show calcification within the lumen...

Chronic kidney disease (CKD) is a state of Klotho deficiency. The Klotho expression may be suppressed due to DNA hypermethylation in cancer cells so we have investigated the effects and possible mechanisms by which Klotho expression is regulated in human aortic smooth muscle cells (HASMCs). The vascular Klotho hypermethylation in radial arteries of patients with end-stage renal disease was desc...

The histology of the calcified aortic valve has been sequentially revisited in the light of modern concepts of cardiovascular pathology. Fifteen cases of calcified aortic valves, surgically removed for an acquired steno-insufficiency, have been investigated by histochemistry (Weigert’s stain, Van Gieson’s stain, Verhoeff’s stain, Alcian blue / PAS stain). Following the lipidic infiltration of t...

BACKGROUND Calcified amorphous tumor of the heart is a rare, non-neoplastic cardiac mass characterized by nodular calcium in the background of amorphous degenerating fibrinous material. Clinical diagnosis of calcified amorphous tumor can be difficult, and current single imaging techniques do not specifically differentiate calcified amorphous tumor from other cardiac tumors such as calcified atr...

Calcific uremic arteriolopathy (CUA)/calciphylaxis is an important cause of morbidity and mortality in patients with chronic kidney disease requiring renal replacement. Once thought to be rare, it is being increasingly recognized and reported on a global scale. The uremic milieu predisposes to multiple metabolic toxicities including increased levels of reactive oxygen species and inflammation. ...

OBJECTIVE Vascular calcification, with its increasing clinical sequelae, presents an important and unresolved dilemma in cardiac and vascular practice. We aimed to identify molecules involved in this process to develop strategies for treatment or prevention. METHODS AND RESULTS Using subtractive hybridization, a novel cDNA, designated vascular calcification-associated factor (VCAF), has been ...

Calcium phosphate is deposited in many diseases, but formation mechanisms remain speculative. Nanobacteria are the smallest cell-walled bacteria, only recently discovered in human and cow blood and commercial cell culture serum. In this study, we identified with energy-dispersive x-ray microanalysis and chemical analysis that all growth phases of nanobacteria produce biogenic apatite on their c...

The aortic heart valve undergoes geometric and mechanical changes over time. The cusps of a normal, healthy valve thicken and become less extensible over time. In the disease calcific aortic stenosis (CAS), calcified nodules progressively stiffen the cusps. The local mechanical changes in the cusps, due to either normal aging or pathological processes, affect overall function of the valve. In t...

After a period of relative senescence in the field of vascular smooth muscle cell (VSMC) research with particular regards to atherosclerosis, the last few years has witnessed a resurgence, with extensive research re-assessing potential molecular mechanisms and pathways that modulate VSMC behaviour within the atherosclerotic-prone vessel wall and the atherosclerotic plaque itself. Attention has ...

INTRODUCTION. METHODS. Staining methods . Chemical methods . THE PROCESS OF DEPOSIT OF CALCIUM SALTS IN BONE. THE PROCESS OF DEPOSIT OF CALCIUM SALTS UNDER PATHOLOGICAL CONDITIONS. In the arterial wall. In chronic inf lammat ion of the pleura. In calcified fibrornata. In the walls of ovar ian and broadl igament cysts. In tubercular nodules. In pancreat ic fat necrosis. ON THE PRESENCE OP SOAPS ...