BACKGROUND We characterized RNA transcript levels for the whole Drosophila genome during normal aging. We compared age-dependent profiles from animals aged under full-nutrient conditions with profiles obtained from animals maintained on a low-calorie medium to determine if caloric restriction slows the aging process. Specific biological functions impacted by caloric restriction were identified ...

Caloric restriction has been demonstrated to extend life span and postpone aging in a variety of species. The recent extension of the caloric restriction paradigm to yeast places the emphasis of the search for the longevity effectors at the cellular level. To narrow the range of potential effectors of the caloric restriction response, we have examined the effects of the histone deacetylases Rpd...

The correlation between the serum level of copper and ceruloplasmin was determined among sarcheshmeh copper workers and compared with Kerman blood bank diners samples. Serum copper was analyzed by atomic absorption spectrophotometry and ceruloplasmin was determined by a caloric enzymatic assay. The concentration of serum copper in the test group was 93+_20.4 mg/ DL which was significantly lower...

Caloric restriction (CR) reduces the rate of aging and increases life span in all small animal species studied to date, but the effects of CR in humans remain uncertain. This review summarizes current knowledge of the effects of CR in nonhuman primates and humans. The results suggest that CR has a range of beneficial effects in nonhuman primates studied under laboratory conditions, and short-te...

The maintenance of normal body weight either through dietary modification or being habitually more physically active is associated with reduced incidence of nonalcoholic fatty liver disease (NAFLD). However, the means by which weight gain is prevented and potential mechanisms activated remain largely unstudied. Here, we sought to determine the effects of obesity prevention by daily exercise vs....

KeyTech CPT CPT Description AUD 92506 Evaluation of speech, language, voice, communication, auditory processing, and/or aural rehabilitation status AUD 92531 Spontaneous nystagmus, including gaze AUD 92532 Positional nystagmus test AUD 92533 Caloric vestibular test, each irrigation (binaural, bithermal stimulation constitutes four tests) AUD 92534 Optokinetic nystagmus test AUD 92543 Caloric ve...

OBJECTIVES Pure tone audiometry and caloric test in patients with herpes zoster oticus were performed to determine the biologic features of the varicella zoster virus (VZV) and the pathogenesis of vestibulocochlear nerve disease in herpes zoster oticus. STUDY DESIGN A retrospective chart review of 160 patients with herpes zoster oticus was designed in order to determine the classic characteri...

an important study in this journal, Wang et al. found short term dietary restriction in middle-aged mice is associated with decreased abundance of senescent cells in the liver (centrilobular hepatocytes) and intestine (crypt enterocytes) [1]. They detected this reduction following 3 months of 26% caloric restriction in 17 month old mice by assaying cellular γH2AX, a protein that associates with...