Non-small cell lung cancer (NSCLC) poses a serious threat to people’s health. Its morbidity and mortality are among the highest all malignant tumors, there is an urgent need for more effective new treatment methods. In recent years, NSCLC immunotherapy has made great progress, first PD-1 inhibitor nivolumab (Nivolumab, O drug) was approved by US Food Drug Administration (FDA) in March 2015, app...

Dendritic cells (DCs) are specialized antigen-presenting in humans and animals that provide antigen-specific T-cell immunity the body. It also establishes a linkage between innate adaptive immune responses. Various studies have shown malignancies or cancer may impair DCs effector functions. now become new molecular target for treatment of cancer. Modified matured could be novel biological modif...

Lung cancer is the top cause of cancer-related fatalities in both men and women around world, second most commonly diagnosed women. For many patients, traditional chemotherapy (CT) fails to give long-term benefit. Moreover, newer medicines targeting activating mutations EGFR or ALK have shown increased response rates over CT minority patients with these mutations; however, majority do not actio...

background breast cancer is the most common malignancy in women around the world so finding new biomarkers for early detection and also study on molecular aspects of breast cancer is valuable. cancer testis genes are a group of genes expressed solely in testis and in a range of human malignancies. objectives in this study we determined the expression of cancer testis genes tsga10, tex101 and od...

Cancer treatments have been transformed with recent advances in cancer immunotherapy.1 As monotherapies, these agents have demonstrated clinical activity across many tumor types. Further advances in the effectiveness of cancer immunotherapies will require targeting antitumor immune response at multiple levels, which may be accomplished through combination approaches. This review discusses the c...

Abstract Background Pancreatic cancer is one of the most common malignant tumors digestive tract, and it has a poor prognosis. Traditional methods are not effective to accurately assess prognosis patients with pancreatic cancer. Immunotherapy new promising approach for treatment cancer; however, some do respond well immunotherapy, which may be related tumor microenvironment regulation. In this ...

Over most of the 20th century, immunotherapy for cancer was based on empiricism. Interesting phenomena were observed in the areas of cancer, infectious diseases, or transplantation. Inferences were made and extrapolated into new approaches for the treatment of cancer. If tumors regressed, the treatment approaches could be refined further. However, until the appropriate tools and reagents were a...

The immune system is active in breast cancer, playing a dual role in tumor progression and in immune surveillance. Infiltrating immune cells are both prognostic and predictive of response to standard breast cancer therapies. Breast cancer vaccines can activate and expand tumor-specific T cells, but have enjoyed minimal clinical success to date. Immune checkpoint blockade is a new approach to ca...

Despite our enormous effort and progress in medicine, cancer remains a top health issue worldwide. According to recent statistics, more than eight million people annually succumb to the disease in the world [1]. It is clear that we must work much harder in order to eliminate this disease in the next several decades. We have a hope, however, that can encourage us to do so and move forward: cance...

Immunotherapy holds tremendous promise for improving cancer treatment. To administer radiotherapy with immunotherapy has been shown to improve immune responses and can elicit the 'abscopal effect'. Unfortunately, response rates for this strategy remain low. Herein we report an improved cancer immunotherapy approach that utilizes antigen-capturing nanoparticles (AC-NPs). We engineered several AC...