Objective To develop and externally validate risk prediction equations to estimate absolute and conditional survival in patients with colorectal cancer. Design Cohort study.Setting General practices in England providing data for the QResearch database linked to the national cancer registry.Participants 44 145 patients aged 15-99 with colorectal cancer from 947 practices to derive the equations....

Telomeres are the protective structure at both ends of each chromoThe decelerating age-adjusted LTL attrition in cancer cases as they some. Telomere length is widely considered a marker of biological aging. For convenience, telomere lengths in human population studies have been predominately measured in peripheral blood leukocytes. Although leukocyte telomere length (LTL) is generally inversely...

background: in northeastern iran there is an area of high incidence of esophageal cancer which is populated by residents of turkmen ancestry. several environmental risk factors for esophageal cancer have been proposed, but the roles of familial and genetic factors have not been studied extensively in the turkmen population. materials and methods: we evaluated the importance of familial risk fac...

Breast cancer is one of the most important medical problems. In this paper, we report the results of using neural networks for breast cancer diagnosis. The theoretical advantage is that posterior probabilities of malignancy can be estimated directly, and coupled with resampling techniques such as the bootstrap, distributions of the probabilities can also be obtained. These allow a researcher mu...

Cancer and its treatments are well-recognized risk factors for venous thromboembolism (VTE). Evidence suggests that the absolute risk depends on the tumor type, the stage or extent of the cancer, and treatment with antineoplastic agents. Furthermore, age, surgery, immobilization, and other comorbid features will also influence the overall likelihood of thrombotic complications, as they do in pa...

Breast cancer is not a singular illness, but comprises a very heterogeneous group of various subtumours with differing prognoses. In general, the survival rate is dependent on specific prognostic factors. These include tumour size, axillary lymph node metastases, distant metastases (TNM classification) and histological differentiation grade. Hypothetically, it should be possible to favourably i...

Accessible online at: www.karger.com/ort Fax +49 761 4 52 07 14 [email protected] www.karger.com Benefits and Risks of Cervical Cancer Screening The mechanism of secondary cancer prevention is based on the detection of precursor lesions that are surgically excised. Hereby, the natural cycle of carcinogenesis is interrupted, and development of cervical cancer is prevented actively. In the c...

Epidemiologic studies linking high serum iron with cancer risks are limited and inconclusive, despite evidence implicating body iron in human carcinogenesis. A cohort of 309,443 adults in Taiwanwho had no history of cancer had serum iron levels tested at the time of recruitment (1997–2008). Initiallymeasured iron levels were associated with subsequent cancer risk by linking individuals with the...

sary diagnostic and therapeutic steps of all examination modalities, the indications for general CRC screening, risk situations, as well as the necessary follow-up intervals after diagnosis and resection [4]. In most cases, CRC develops via precursor lesions, socalled polyps or adenomas, the progression of which through accumulation of genetic changes is well known (adenomacancer sequence). An ...