Candida spp especially non albicans Candida are increasingly being isolated from clinical specimens. The conventional methods of identification are time consuming and difficult to perform. The study was done to evaluate the performance of conventional identification method (phenotypic and biochemical) and commercially available chromogenic Candida speciation media (CHROM agar) for the identific...

Although Candida albicans cph1/cph1 efg1/efg1 mutant cells are not lethal to mice, they proliferated in infected mice instead of simply being cleared by the host immune system. Here, we have shown that the cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by the lethal wild-type Candida albicans cells. Our results further indicate that a second dose of the cph1/cph1 ef...

Results From a total of 887 isolates, Candida albicans remains a major pathogen accounted for 50.3%, followed by C. tropicalis(27.4%), C. parapsilosis (12.5%), C.guilliermondii (6%), C. glabrata (1.8%), C. krusei (0.23%), C. rugosa (0.23%), and unidentified species(1.6%). From a total of 103 C. albicans, amphotericin B MIC ranged from 0.016-1ug/ml whereas fluconazole MIC ranged were between 0.0...

Aminopiperidine derivatives, Compound 1a and 1b, are novel small molecules that inhibit C-14 reduction catalyzed by Erg24p in ergosterol synthesis of Candida albicans. We evaluated the properties of the in vitro and in vivo activities of these compounds against pathogenic fungi and compared their activities with those of fluconazole. Compound 1a and 1b exhibited potent in vitro activities again...

Phagocytosis is a critical function of polymorphonuclear leukocytes in the control of mycotic infections. By using a modified fluorescence quenching assay to distinguish between attached and ingested organisms, we determined the percent phagocytosis of several medically important yeasts. The percentages of phagocytosis of serum-opsonized Candida albicans, Candida tropicalis, Candida parapsilosi...

It is known that pulmonary moniliasis may complicate treatment with antibiotics (Wolff, 1952; annotations in the Lancet, 1951, 1952; Werner, 1953; Browne, 1954; Bratlund and Holten, 1954). Recently Bratlund and Holten (1954) have reported cases of moniliasis during treatment with cortisone or corticotrophin. Viable Candida albicans has not been found outside the living organism (Nilsby and Nord...

The present study was undertaken to investigate the effectiveness of the ethanolic extract of Echinophora platyloba DC. on Candida albicans. Using the agar dilution method, the growth condition of standard Candida albicans ATCC 10231, cultured on the media containing plant extracts at different concentrations (1,2,4,8,16,32,64,128 and 256 mg/ml) was studied. The results were recorded twenty one...

The present study was undertaken to investigate the effectiveness of the ethanolic extract of Echinophora platyloba DC. on Candida albicans. Using the agar dilution method, the growth condition of standard Candida albicans ATCC 10231, cultured on the media containing plant extracts at different concentrations (1,2,4,8,16,32,64,128 and 256 mg/ml) was studied. The results were recorded twenty one...

The aim of our study was to evaluate the accuracy of the chromogenic media Albicans ID2® (bioMérieux, France) for the identification of Candida albicans among 330 yeast strains. All C. albicans (100) and C. dubliniensis (20) strains exhibited blue color when cultured on Albicans ID2®. However, the blue color was also exhibited by cultures of C. rugosa (30/30) and C. tropicalis (3/50) isolates.