Candidiasis is a major health concern causing both morbidity and mortality. The increasing prevalence of antimicrobial-resistant fungi associated with life-threatening systemic mycoses, led constant need for new antifungal agents. Herbal medicines have been tried this purpose centuries. effect fig tree latex has reported some trace elements such as zinc were effects. aim study was to determine ...

A microdilution assay using Alamar Introduction Blue, a colorimetric indicator, was compared with the NCCLS macrodilution broth assay for voriVoriconazole is a new triazole agent that appears to have a broader spectrum of antifungal activity conazole, fluconazole, and itraconazole against Candida albicans, Candida glabrata, and Candida krusei. than the parent compound, fluconazole [1–6]. Prior ...

Background and Purpose: Annually affecting millions of women, vulvovaginal candidiasis (VVC) is commonly described by signs and symptoms of vulvovaginal inflammation in the presence of Candida species. Today, the detection of the virulence factors plays a major role in the understanding of pathogenesis of candidiasis and helps produce new anticandidial drugs to improve its treatment efficiency....

Candidiasis, which includes both superficial infections and invasive disease, is the most common cause of fungal infection worldwide. Candida bloodstream infections (BSI) cause significant mortality and elicit a major threat to intensive care unit (ICU) patients [1]. The annual global burden of Candida spp. BSIs is about 400,000 cases, with most cases reported from the developed world. Although...

BACKGROUND Bloodstream infections (BSIs) caused by Candida glabrata have increased substantially. Candida glabrata is often associated with resistance to fluconazole therapy. However, to our knowledge, risk factors for fluconazole-resistant C glabrata BSIs have not been studied. METHODS A case-case-control study was conducted at 3 hospitals from January 1, 2003, to May 31, 2007. The 2 case gr...

OBJECTIVE To identify Candida species in asymptomatic subjects in Bobo-Dioulasso (Burkina Faso) by the matrix-assisted laser desorption ionization-time of flight mass spectrometry. METHODS A cross-sectional study was conducted from January to February 2013 in Bobo-Dioulasso to collect fecal and urine specimens from voluntary donors. Fungal strains were isolated on Sabouraud dextrose agar and ...

Fungal infections have emerged as a world-wide health care problem in recent years, owing to the extensive use of broad-spectrum antibiotics. We screened 104 pregnant women with symptoms of vaginal candidiasis in the antenatal clinic of Thika District Hospital, Kenya in order to identify vaginal Candida species and determine their susceptibility profile to commonly used antifungal drugs for tre...

conclusions in this study, snpcr was specific and more sensitive than the chromogenic medium chromagar™ candida for the detection of candida spp. insofar as it failed to identify only a few isolates. materials and methods we used snpcr with universal and species-specific primers to detect candida species in the culture of clinical isolates. by using universal primers, we carried out the amplifi...

BACKGROUND Vulvovaginal candidiasis (VVC) is the second most common vaginal infection. HIV-infection is a risk factor for this infection. OBJECTIVE To determine the frequency of VVC and to describe the main Candida species isolated and their susceptibility to antifungal drugs in HIV-infected patients, compared to HIV-uninfected women in Salvador, Brazil. METHODS Cross-sectional study includ...

background: nowadays candida albicans has become resistant to the toxic and expensive commercial anti-candida drugs. therefore, investigation for new anti-fungal agents is necessary. objectives: the purpose of this survey was to investigate the in vitro anti-candida activity of the hydroalcoholic extracts of heracleum persicum fruit. materials and methods: the plant ingredients were extracted u...