The pathogenesis behind diabetic microangiopathy is complex; both genetic (1–3) and metabolic factors (4–6) are clearly of importance. Recently, it has been demonstrated that not only patients with diabetes but also healthy individuals at risk for diabetes have functional vascular disturbances (7). These findings suggest that factors other than hyperglycemia are of importance for microvascular ...

Microvascular circulation creates a supporting niche for neurogenesis through the secretion of angiocrine factors. The emerging concept that energy balance and metabolic status play a role in the modulation of stem cells suggests that oxygen delivery by nearby capillary vascular beds could also regulate neurogenesis. Blood vessel formation and neuron production proceed in a coordinated fashion ...

References HAMPTON, J.R. & MITCHELL, M.R.A. (1966) Abnormalities of platelet behaviour in acute illness. British Medical Journal, 51, 1079 JAN, KUNG-MING, CHIEN, SHU & BIGGER, J.T., JR (1975) Observations on blood viscosity changes after myocardial infarction. Circulation, 51, 1079. KASABACH, H.H. & MERRITT, K.K. (1940) Capillary hemangioma with extensive purpura. American Journal of Diseases o...

YUDILEVICH, D. L., AND NORINA DE ROSE. Blood-brain transfer of glucose and other molecules measured by rapid indicator dilution. Am. J. Physiol. 220(3) : 841-846. 197 1 .-The blood-brain barrier (BBB) of the dog was studied in vivo, by means of the first-passage multiple-tracer dilution technique. Venous samples were obtained at the rate of 3-5/set, for about 5 sec. The labeled molecules used w...

The phase 1 clinical trial of systemic Targeted Alpha Therapy for metastatic melanoma has shown that solid tumours can be regressed by alpha radiation. However, patient blood vessels and lymphocytes inevitably received a background radiation from non-targeted alpha decays in the blood circulation. To determine the toxicity of alpha particle to normal tissue capillaries and peripheral blood lymp...

Previously we showed that cardiopulmonary bypass (CPB) during cardiac surgery is associated with reduced sublingual microcirculatory perfusion and oxygenation. It has been suggested that impaired microcirculatory perfusion may be paralleled by increased heterogeneity of flow in the microvascular bed, possibly leading to arteriovenous shunting. Here we investigated our hypothesis that acute hemo...

Intranasal administration provides a non-invasive drug delivery route that has been proposed to target macromolecules either to the brain via direct extracellular cranial nerve-associated pathways or to the periphery via absorption into the systemic circulation. Delivering drugs to nasal regions that have lower vascular density and/or permeability may allow more drug to access the extracellular...

More than 5035 of tracer rubidium entering the coronary circulation is actively taken up by the heart muscle cells during a single passage. Rubidium ions must traverse the capillary wall, the interstitial space, and the muscle cell membrane to enter the very large potential rubidium pool within the cells. The aim of this investigation was to determine which, if any, of these steps are rate limi...

In normal gravity, lung diffusing capacity (DL(CO)) and lung tissue volume (LTV; including pulmonary capillary blood volume) change in concert, for example, during shifts between upright and supine. Accordingly, DL(CO) and LTV might be expected to decrease together in sitting subjects in hypergravity due to peripheral pooling of blood and reduced central blood volume. Nine sitting subjects in a...

Pulmonary oedema (PO) can emerge from mechanical disorders in pulmonary circulation leading to elevated fluid filtration in the lung, or from increased vascular permeability due to inflammatory or toxic injury of the alveolar-capillary barrier. A number of these disorders causing PO is associated with increased catecholamine (CA) levels in plasma and lung tissue and/or increased sympathetic act...