Inhibition of mammalian hexokinase by glucose g-phosphate was first reported by Weil-Malherbe and Bone (1) and studied by Crane and Sols (2). An inhibition of rabbit muscle phosphofructokinase by excess adenosine triphosphate was observed by Lardy and Parks (3) and was shown to be reversed by a number of intracellular components by Passonneau and Lowry (4). Similar findings were reported on the...

Enzyme systems concerned in the breakdown of carbohydrates by dennatophytes have been little studied, the principal contribution being a study of a number of enzymes of the glycolytic and hexosemonophosphate pathways and of the tricarboxylic acid cycle in cell-free extracts of Trichophyton mentagrophytes (Jensen, Altschuller & Bard, 1957). The effect of different substrates and pH values on the...

The liver provides for long-term energy needs of the body by converting excess carbohydrate into fat for storage. Insulin is one factor that promotes hepatic lipogenesis, but there is increasing evidence that glucose also contributes to the coordinated regulation of carbohydrate and fat metabolism in liver by mechanisms that are independent of insulin. In this study, we show that the transcript...

Warburg, Posener, and Kegelein (1) discovered the important fact that surviving tumor tissue showed an unusually large glycolytic power when compared with other tissues under identical experimental conditions. All other tissues including embryonic tissue showed some glycolysis in the absence of oxygdn, but practically none when oxygen was present, while the glycolytic power of tumor cells was o...

The inhibition of glycolysis by respiration (Pasteur effect) and the inhibition of respiration by glycolysis (Crabtree effect) represent nonhormonal regulatory mechanisms of cellular metabolism. Some of the previous work on these phenomena in intact cells will be reviewed in subsequent papers (1, 2) together with a report on recent experimental work on ascites tumor cells. The difficulty of obt...

The relationship of vitamin Br to carbohydrate metabolism was one of the earliest functions of a vitamin to be observed. The problem has been more or less continuously investigated up to the present time and the majority of the evidence indicates that in vitamin B1 deficiency there is some interference with glycogen storage, hyperglycemia, and characteristic errors in carbohydrate metabolism. E...

The effects of aluminium and aluminium-citrate on some serum parameters related to carbohydrate metabolism in male Wistar rats were investigated. Daily intraperitoneal administrations of 1 mg/kg body weight of aluminium or aluminiumcitrate (1: 1) for 50 days led to the elevation of serum insulin by 24 or 40 percent respectively, with the concomitant decrease in serum glucose concentrations ...

Abnormalities in maternal folate and carbohydrate metabolism have both been shown to induce neural tube defects (NTD) in humans and animal models. However, the relationship between these two factors in the development of NTDs remains unclear. Data from mothers of children with spina bifida seen at the Unidad de Espina Bífida del Hospital Infantil Virgen del Rocío (case group) were compared to m...

If the reader would integrate the intermediary metabolism of lipids with that of carbohydrates let him read, albeit in reverse direction, Dr. Peters' chapters on lipids and carbohydrate in Grollman's text,' the article on "The interrelations of foodstuffs in metabolism" in the 1951 Yale Journal of Biology and Medicine,' the chapter on lipids in the 1946 edition of Quantitative clinical chemistr...

Fat and carbohydrate are important fuels for aerobic exercise and there can be reciprocal shifts in the proportions of carbohydrate and fat that are oxidized. The interaction between carbohydrate and fatty acid oxidation is dependent on the intracellular and extracellular metabolic environments. The availability of substrate, both from inside and outside of the muscle, and exercise intensity an...