The spectrophotometric method of Commins and Lawther (I965) for the determination of carboxy-haemoglobin saturation in blood was found to lead to systematic undervaluation, because of dissociation of the carboxyhaemoglobin, and physical dissolution of the carbon monoxide in the solvent used for the analysis. The theoretical relationship between the true and apparent carboxyhaemoglobin saturatio...

Mitochondrial dysfunction contributes to brain injury following global cerebral ischemia after cardiac arrest. Carbon monoxide treatment has shown potent cytoprotective effects in ischemia/reperfusion injury. This study aimed to investigate the effects of carbon monoxide-releasing molecules on brain mitochondrial dysfunction and brain injury following resuscitation after cardiac arrest in rats....

The method to be described for the determination of hemoglobin depends upon the comparison, in a calorimeter, of carbon monoxide hemoglobin solutions, one of which has a known hemoglobin content. Hoppe-Seyler (1) was the first to describe carbon monoxide hemoglobin and to make use of this stable combination for estimating the hemoglobin content of blood. He devised a “double pipette” for compar...

Carbon monoxide poisoning as a suicide method is relatively uncommon in Malaysia. Available data reported that the rate for suicide by carbon monoxide poisoning accounted for less than 1% in Malaysia in 1995 and the figure remained the same in 2011 [1]. The health risks associated with carbon monoxide vary with its concentration and duration of exposure. The toxic effects range from subtle card...

The method to be described for the determination of hemoglobin depends upon the comparison, in a calorimeter, of carbon monoxide hemoglobin solutions, one of which has a known hemoglobin content. Hoppe-Seyler (1) was the first to describe carbon monoxide hemoglobin and to make use of this stable combination for estimating the hemoglobin content of blood. He devised a “double pipette” for compar...

Carbon monoxide is a comparative rarity among the biologically generated C, compounds. It has been found in large concentration only in the hollow stems of the kelp, Nereocy8tis (Blinks, 1951), and in the float of the Portuguese man-of-war, Phy8atia physalia L. (Wittenberg, 1958, 1960). A glandular structure, the gas gland or pneumadena, formed by localized modification of the inner wall of the...

Inhalation of small amounts of carbon monoxide diminishes the pain threshold in patients with stable angina pectoris. The aim of this study was to identify and describe patients who had been exposed unknowingly to toxic inhalations of this gas and subsequently presented to hospital with a clinical picture of unstable angina. Blood carboxyhaemoglobin levels of 104 patients referred with unstable...

STUDY OBJECTIVE We determine whether maintaining normocapnia during hyperoxic treatment of carbon monoxide-exposed research subjects improves cerebral oxygen delivery. METHODS This experiment used a randomized, single-blinded, crossover design. We exposed 14 human research subjects to carbon monoxide until their carboxyhemoglobin levels reached 10% to 12%. We then treated each research subjec...

BACKGROUND More needs to be known about the prevalence of risk and protective factors for fires, burns, and carbon monoxide poisoning in U.S. households. METHODS A random-digit-dial survey was conducted about home safety with 1003 respondents representing households in the continental United States. Descriptive statistics assess the prevalence of risk and protective factors for fires, burns, ...

The first allylic carbonylation reaction of allylic acetates with aryl boronic acids under carbon monoxide has been developed. Using Pd-PCy3 as a catalyst, a wide spectrum of allylic acetates was carbonylated in the presence of various aryl boronic acids, affording α,β-unsaturated aryl ketones in good to excellent yields. Preliminary studies indicate that carbon monoxide always inserts at the l...