The folding of proteins is directed by a variety of interactions, including hydrogen bonding, electrostatics, van der Waals’ interactions, and the hydrophobic effect. We have argued previously that an n!p* interaction between carbonyl groups be added to this list. In an n!p* interaction, the lone pair (n) of one carbonyl oxygen overlaps with the p* antibonding orbital of another carbonyl group....

This paper studied the pollution characteristics of shale oil refinery wastewater, by using conventional analysis, infrared spectroscopy, ultraviolet chromatography and mass spectrometry. The results showed that: wastewater contains high concentration dissolved organic matter, which was poor in biological treatment. structure groups such as benzene ring, carbonyl group, hydroxyl ether group car...

D-(-)-ribose was subjected to oxidation with equimolar amounts of H20 2/Fe2+ and 13-hydroperoxy-9-c/s-l l-fra/75-octadecadienoic acid/Fe2+. Smaller carbohydrates, carbonyl compounds, hydroxy acids and polyols were produced. Identification of carbonyl compounds was achieved by trapping with pentafluorobenzylhydroxylamine hydrochloride (PFBHA-HC1). All products were identified by GC/MS after deri...

Increasing antibiotic resistance urgently requires novel therapeutic options to combat bacterial infections. The anti-virulence therapy selectively intervening with pathogenicity without affecting bacterial viability is such a strategy to overcome resistance. We consider the virulence regulator PqsR as an attractive target in the human pathogen Pseudomonas aeruginosa, and recently discovered th...

We report here the synthesis of divalent ligands containing 3-deoxy-4-thiolactose. This thiodisaccharide has been synthesized using the Michael addition of β-1-thiogalactose to the α,β-unsaturated system of sugar-derived dihydropyranones, followed by the reduction of the remaining carbonyl group. We were able to control the configuration (S) of the stereocenter linked to sulfur (C-4) of the red...

In the title compound, C(26)H(23)ClFN(5)O(2)S(2), the mean plane of the guanidine fragment makes dihedral angles of 58.94 (13), 78.37 (17) and 50.76 (15)°, respectively, with the attached thia-zole, pyridine and phenyl rings. The crystal structure features N-H⋯S and C-H⋯O hydrogen bonds and weak π-π stacking inter-actions [centroid-centroid separation = 3.7702 (17) Å]. The terminal methyl group...

The title compound, C(23)H(24)BrNO(4), crystallizes with two independent mol-ecules per asymmetric unit. The methyl group of the ethoxy-carbonyl unit is disordered over two positions, with occupancies of 0.715 (12) and 0.285 (12) in one of the independent mol-ecules, and 0.529 (11) and 0.471 (11) in the other mol-ecule. In one of the independent mol-ecules, the tetra-hydro-pyridine ring adopts ...