Nitroglycerin (NTG) is an organic nitrate rapidly denitrated by enzymes to release free radical nitric oxide and shows improved wound healing and tissue protection from oxidative damage. The purpose of this study was to evaluate whether topical application of NTG in the form of gel/ointment along with a natural wound healing agent, aloe vera, would bring about wound healing by using diabetes-in...

Ciprofloxacin, an antibacterial agent, is having low solubility in aqueous solution and high rate of absorption from the stomach. It is precipitated at alkaline pH leading to erratic absorption of the drug from small intestine. To overcome these difficulties, controlled release mucoadhesive suspensions have been designed so that safe and effective blood level of Ciprofloxacin can be maintained ...

In present study mucoadhesive buccal tablet of simvastatin was prepared. Solubility of Simvastatin was enhanced by complexing Simvastatin with β-CD in 1:2 molar concentrations. Six different formulations of tablets of Simvastatin containing the polymers in various combinations were prepared by direct compression method and characterized for swelling studies, % matrix erosion, surface pH, mucoad...

Swellable elementary osmotic pump (SEOP)utilizes the osmotic pressure and polymer-swelling force to deliver drugs to the GI tract in a reliable and reproducible manner.Metoprolol and ramipril are one of the combinationsindicated in the management of hypertension in patients with heart failure and post myocardial infarction. This combination was selected to develop SEOP to release the drugs cont...

The present study concerned with the development and characterization of metronidazole microcapsules prepared by thermal change method using different ratios (1:1, 1:2 and 1:4) of ethyl cellulose in order to select the best microcapsule formulation with a good encapsulation efficiency and drug release profile. The obtained microcapsules were discrete, spherical with free flowing properties and ...

The world coffee consumption has been growing for its appreciated taste and its beneficial effects on health. The residual biomass of coffee, originated in the food industry after oil extraction from coffee beans, called coffee beans residual press cake, has attracted interest as a source of compounds with antioxidant activity. This study investigated the chemical composition of aqueous extract...

Safe and effective manipulation of soft tissue during laparoscopic procedures can be achieved by the use of mucoadhesive polymer films. A series of novel adhesive polymer films were formulated in house based on either Carbopol or Chitosan modified systems. The mechanical properties of the polymers and their adherence to bowel were evaluated using ex-vivo pig bowel immersed in 37°C water bath an...

The prolonged release gliclazide matrix tablets were prepared using polymeric materials, namely, HPMC, Kollidon SR, Carbopol with Xanthan gum, Eudragit RSPO and Eudragit RLPO. HPMC, Kollidon SR and Carbopol with Xanthan gum were able to retard gliclazide release from matrix tablets in a concentration dependent manner, but the rate of retardation differed among the polymers. On the other hand, d...

The antidiabetic properties of prosopis gum alone and as a bioadhesive base for the delivery of metformin are presented. The bioadhesive value of the gum was commensurate with those of Carbopol 974-P and sodium carboxymethyl cellulose (NaCMC). The release of the drug was higher from prosopis gum based bioadhesive formulations than from NaCMC and Carbopol 974-P products. This was shown by the sh...

The present research has been undertaken with the aim to develop a transdermal gel formulation of naproxen, which would attenuate the gastrointestinal related toxicities associated with oral administration. The potential gastrointestinal disorders associated with oral administration of naproxen (NSAID’s) can be avoided by delivering the drug to the inflammation site. Gel based formulations are ...