Urocortins are human homologues of urotensin I, a fish corticotropin-releasing-factor- (CRF-) like peptide secreted from the urophysis. There are three urocortins: urocortin 1, urocortin 2, and urocortin 3 in mammals. We have shown that urocortin 1 and urocortin 3 are endogenously synthesized in the myocardial cells of human heart and may act on CRF type 2 receptor (CRFR2) expressed in the hear...

A historical account is presented of the development of sex hormone treatment from its beginning at the Peking Union Medical College to its present-day generalization throughout China. The general theme of this work has been to test low-dose hormone regimens. Notable successes include low-dose oral contraception and menopausal hormone treatment. In support of the latter, we present a new clinic...

With a 2030 projection of 23.6 million deaths per year, the prevalence and severity cardiovascular disease are astoundingly high. Thus, there is definitive need for identification novel compounds with potential to prevent or treat associated states. Moreover, also an ever-increasing drug delivery systems (DDS) that cope poor ranging physiochemical properties therapeutic achieve clinical effect....

Abstract Background Homeostatic regulation of cardiomyocytes is indispensable in maintaining the normal physiological activity cardiac tissue. Cardiotoxicity induced by drugs may lead to abnormalities such as arrhythmia, myocardial infarction and hypertrophy. Moreover, drug-induced cardiotoxicity confines additional use implicated drugs. Several studies have reported that consumption phytochemi...

Food bioactive compounds have a beneficial biological effect on human health, fending off cancer, cardiovascular disease, metabolic syndrome, and neurodegenerative among other noncommunicable diseases disorders. Secondary metabolites like polyphenols, glucosinolates, carotenoids, vitamins, terpenoids, saponins, fibers been linked to these health benefits due their antioxidant, antiatherogenic, ...

Ectopic fat accumulation in the liver causes nonalcoholic fatty liver disease (NAFLD), which is the most common cause of chronic liver disease in Western countries. Ectopic liver lipid, particularly diacylglycerol, exacerbates hepatic insulin resistance, promotes systemic inflammation, and increases risk of developing both type 2 diabetes mellitus and cardiovascular disease. Increasing evidence...

Emerging evidence strongly suggests that dietary nitrate, derived in the diet primarily from vegetables, could contribute to cardiovascular health via effects on nitric oxide (NO) status. NO plays an essential role in cardiovascular health. It is produced via the classical L-arginine-NO-synthase pathway and the recently discovered enterosalivary nitrate-nitrite-NO pathway. The discovery of this...