Off-pump coronary artery bypass surgery reduces the myocardial injury associated with on pump surgery with cardiopulmonary bypass (CPB) and ischemic-cardioplegic arrest (CA). We sought to find a mechanistic explanation for this by comparing the transcriptomic changes in the myocardium of patients undergoing on- and off-pump surgery. Transcriptomic analyses were performed on left ventricular bio...

Cardiovascular disease is the leading cause of death in the United States and most developed countries. The majority of deaths are due to coronary artery disease. It is estimated that 419,000 coronary artery bypass grafting (CABG) procedures were performed in the United States in 2009 for the surgical treatment of coronary artery disease. Off-pump CABG (without the use of cardiopulmonary bypass...

Penetrating trauma to the chest leading to coronary artery injury is associated with a high mortality rate, especially in the case of injury to the left anterior descending (LAD) coronary artery. The mortality rate remains high whether they are managed with primary ligation or with coronary artery bypass grafting using conventional cardiopulmonary bypass techniques. We report a case of proximal...

PURPOSE To compare cardiac function assessed by intraoperative transesophageal echocardiography in patients undergoing cardiac revascularization with or without cardiopulmonary bypass. MATERIAL AND METHODS Forty-one patients scheduled for elective, isolated cardiac revascularization (21 on-pump and 20 off-pump) were prospectively analyzed. Patients were matched for demographic (age and gender...

STUDY OBJECTIVES Cardiopulmonary bypass (CPB) represents a specific risk factor for renal damage during coronary revascularization. The purpose of this study was to compare the perioperative renal damage in patients undergoing on-pump and off-pump coronary surgery. DESIGN AND PATIENTS The progress and extent of renal damage was prospectively studied in two groups of patients undergoing cardia...

PURPOSE Impacts on hemolysis and backflow using a non-occlusive setting with the Better-Header (BH) roller pump were investigated. METHODS AND RESULTS Pump flow of a non-occlusion setting was measured with a pump speed of 3 L/min and 5 L/min against various after-loads. With the non-occlusive setting (BH-NO350), backflow was less than 10% if the pump pressure head was <300 mmHg. When the outl...

CHEST,81: 3, MARCH,1982 pump oxygenators. Ann Thorac Surg 1980; 29:336 2 Pierce EC II. Specific therapy for arterial air embolism (edictorial). Ann Thorac Surg 1980; 29:300 3 Mills NL, Ochsner JL. Massive air embolism during cardiopulmonary bypass : cause, prevention and management. J Thorac Cardiovasc Surg 1980; 80:708 4 Coss CM. Gray’s anatomy (27th ed). Philadelphia: Lea & Febiger, 1959, Fig...

We report the case of a patient unweanable from cardiopulmonary bypass who underwent transaortic implantation of an Impella Recover LD blood pump. The ventricular assistance afforded an adequate flow but the patient died 48 hours after due to severe ischemia of the lower limbs. Chronic atherosclerotic occlusion of the abdominal aorta could be observed during the necropsy study as well as a sube...

Subjects: 174 adults who had cardiac surgery with cardiopulmonary bypass. Subjects undergoing off-pump surgery, aged <18 years, or with relative contraindications to the use of the esophageal Doppler probe, such as esophageal disease, were excluded. Subjects were also excluded postoperatively if on admission to intensive care there was excessive bleeding, unstable arrhythmias, a need for intra-...

Coronary artery bypass grafting (CABG) using cardiopulmonary bypass (CPB) and cardioplegic arrest has been performed safely over several decades. Cardiac surgery under cardiac arrest provides a bloodless stable operative field, that can facilitate anastomosis. In last decade, CABG without CPB, off-pump CABG (OPCAB) has become more common with advances in surgical instruments and technique. This...