During Drosophila eye development, a Ras cascade mediates the decision between neuronal and non-neuronal differentiation of the R7 photoreceptor precursor. Recent genetic and molecular studies have identified a set of protein kinases as components of the Ras cascade and nuclear targets of the cascade, including Yan, Pointed, Jun, and Phyllopod. The Ras cascade functions in other Drosophila sign...

Organ damage after reperfusion of previously viable ischemic tissues is defined as ischemia/reperfusion injury. The pathophysiology of ischemia/reperfusion injury involves cellular effect of ischemia, reactive oxygen species and inflammatory cascade. Protection against ischemia/reperfusion injury may be achieved by preconditioning or postconditioning. In this review, we discuss basic mechan...

It is demonstrated that (3Z)-nonenal (NON) and (3Z)-hexenal (HEX) are oxidized in a cascade by lipoxygenase (LOX) and hydroperoxide peroxygenase (HP peroxygenase) into (2E)-4-hydroxy-2nonenal (HNE) and (2E)-4-hydroxy-2-hexenal (HHE), respectively. In turn, HNE inactivates LOX terminating the cascade. The hydroxy-alkenals produced serve to inhibit plant pathogens, which initiated the cascade. In...

The atomic cascades in µ − p and ¯ pp atoms have been studied in detail using new results for the cross-sections of the scattering of highly excited exotic atoms from molecular hydrogen. The cascade calculations have been done with an updated version of the extended standard cascade model that computes the evolution in the kinetic energy from the beginning of the cascade. The resulting X-ray yi...

Invasive gastric carcinoma is preceded by a cascade of precancerous lesions. The first recognized histologic change is active chronic inflammation, which may persist as such: non-atrophic chronic gastritis (no gland loss), or advance to multifocal atrophic gastritis (MAG), the first real step in the precancerous cascade. The following steps are: intestinal metaplasia (first "complete" and then ...

First-order theory refinement using neural networks is still an open problem. Towards a solution to this problem, we define a First-Order extension of the Cascade ARTMAP (FOCA) system, using Inductive Logic Programming techniques. To present such a first-order extension of Cascade ARTMAP, we: a) modify the network structure to handle first-order objects; b) define firstorder versions of the mai...

The security of cascade blockcipher encryption is an important and well-studied problem in theoretical cryptography with practical implications. It is well-known that double encryption improves the security only marginally, leaving triple encryption as the shortest reasonable cascade. In a recent paper, Bellare and Rogaway showed that in the ideal cipher model, triple encryption is significantl...

In the mid-infrared spectral region, where continuous wave room temperature operation of the QCL devices was achieved in the previous phase of the program, the main goal will be to further broaden the frequency range over which these high performances are achieved. Another important topic is the fabrication of devices with a very large frequency tuning capability, which will enable the spectros...

A hierarchical approach, in which a highdimensional model is decomposed into series of low-dimensional sub-models connected in cascade, has been shown to be an effective way to overcome the ’curse of dimensionality’ problem. Information propagation through a cascade hierarchy of Linguistic Decision Trees (LDTs) based on label semantics forms a process of cascade decision making. In order to exa...

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR-associated (Cas) systems of type I use a Cas ribonucleoprotein complex for antiviral defense (Cascade) to mediate the targeting and degradation of foreign DNA. To address molecular features of the archaeal type I-A Cascade interference mechanism, we established the in vitro assembly of the Thermoproteus tenax Cascade from...