OBJECTIVE To study the clinical and pathological characteristics of patients with intestinal tuberculosis. DESIGN Retrospective study. SETTING United Christian Hospital, Hong Kong. PATIENTS Patients with intestinal tuberculosis diagnosed between January 1995 and December 2004 inclusive. RESULTS The median age of the 13 male and 9 female patients was 53 years (range, 12-81 years). Ninete...

BACKGROUND Sarcoidosis is a multi-system disease characterized by the presence of non-caseating epithelioid granulomas in affected tissues, including skeletal muscle. These organized collections of immune cells have important pathophysiologic action including cytokine production leading to inflammation as well as enzymatic conversion of cholecalciferol to calcitriol via 1-α hydroxylase. There a...

OBJECTIVE To compare and analyze the clinical, radiological, and pathological features of solitary or/and multiple CNS tuberculomas (CNSTs). METHODS The study was conducted at Central South University, First Xiangya Hospital, Changsha, Hunan, China between 1998-2008. Forty-two subjects with diagnosed CNSTs were compared and analyzed by multiple or solitary lesions seen on enhanced MRI. The fi...

abstract background: the varieties of treatment methods for the scaphoid non:::::union::::: have always been a discussable issue for orthopaedic surgeons. the current study, considered to be review for treatment results of the patients who sustained the scaphoid non:::::union::::: with or without avascular necrosis and compared these two groups clinically and radiologically. methods: the clinic...

The recent identification of genetic mutations leading to dysfunction of inflammatory and apoptotic pathways, has allowed to characterise a group of diseases, recognised as monogenic autoinflammatory syndromes. Among those, Blau syndrome (BS) and early-onset sarcoidosis (EOS) have been identified as familial and sporadic phenotypes of the same non-caseating granulomatous form. Both the diseases...

BACKGROUND Imatinib mesylate (IM) is the standard treatment for BCR-ABL-positive chronic myelogenous leukemia (CML) and is the first-line adjuvant and palliative treatment for metastatic and inoperable gastrointestinal stromal tumor (GIST). IM is not known to be associated with an increased risk for development of granulomatous diseases. METHODS We describe our experience with 2 patients (42 ...

BACKGROUND Granulomatous inflammation has been previously reported in association with cancer. Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) is a new minimally invasive test for investigating mediastinal lymphadenopathy. The identification of granulomatous inflammation by EBUS-TBNA and the clinical implications of such detection in a series of patients with previo...

INTRODUCTION Mycobacterium gordonae is one of the least pathogenic of the mycobacteria. This pathogen may produce caseating or non-caseating granulomas, and skin lesions showing acute or chronic inflammation with scattered histiocytes and giant cells have been seen. The mortality rate is less than 0.1%. Mycobacterium gordonae may be a marker of severe immunosuppression in patients infected with...