OSW-1 is a new member of cholestane saponin family, which is cytotoxic against several types of malignant cells. We reported herein that OSW-1 induced apoptosis of mammalian cells in a concentration- and time-dependent manner. The drug-induced apoptosis was mediated through the mitochondrial pathway, involving the cleavage of Bcl-2. This drug-induced Bcl-2 cleavage in Chinese hamster ovary (CHO...

Abstract NLRP3 is a cytosolic sensor protein in myeloid leukocytes that recruits the adaptor ASC and activates caspase-1 functional inflammasomes. Caspase-1 coordinately cleaves pro-IL-1β to bioactive IL-1β gasdermin D (GSDMD) induce N-GSDMD macropores plasma membrane (PM). The latter mediate efflux of mature initiate progression pyroptosis, lytic cell death. activation triggered by perturbed c...

Background Safflor yellow (SY) is a water-capacitive component of dried flowers, mainly from safflor in the safflower family, which contains large amount bruthin A, or A (SYA) for short. Studies have reported protective effects SYA against oxidative stress injury nerve cells. Materials and Methods In this study, H 2 O -treated PC12 cells were used as experimental materials to explore how plays ...

BACKGROUND Alpha 1-antitrypsin (A1AT) is a 52 kDa serine protease inhibitor produced largely by hepatocytes but also by mononuclear phagocytes. A1AT chiefly inhibits neutrophil elastase and proteinase-3 but has also been reported to have immune modulatory functions including the ability to inhibit caspases. Its clinical availability for infusion suggests that A1AT therapy might modulate caspase...

Introduction Conclusions References

objective(s): increasing cytokines and reactive oxygen species (ros) during ischemia reperfusion (i-r) leads to the lung damage. adalimumab (ada) is a potent tumor necrosis factor-alpha (tnf-α) inhibitor agent. we aimed to evaluate whether ada would prevent the lung tissue from damage development over the i-r process. materials and methods:twenty seven wistar albino male rats were divided into ...