TAFRO syndrome is defined by the presence of thrombocytopenia, hydrops, fever, fibrosis, renal dysfunction, and organomegaly can be seen with idiopathic multicentric Castleman disease (iMCD) or as an isolated process without iMCD. The pathophysiology not well understood, but it thought to related hypercytokinemia. Subclinical hypothyroidism may a potential factor in pathogenesis symptomatology ...

Multicentric Castleman disease (MCD) is an uncommon systemic lymphoproliferative disease. The diagnosis of this typically challenging and requires collaboration between clinicians pathologists. Moreover, it important to exclude other diseases (such as malignancies, autoimmune diseases, infectious diseases) that have similar clinical manifestations pathological findings. Patients with untreated ...