The role of inflammation has been shown in the pathogenesis of epilepsy, while glucocorticoids and adrenaline have anti-inflammatory effects. The aim of the present study was to investigate the effects of adrenaline, prednisolone, and indomethacin on caffeine-induced epilepsy (epileptiform activity) in rats and to examine the mechanism of the pro-epileptic effect of indomethacin. The adrenalect...

Bivalve metamorphosis is a developmental transition from free-living larva to benthic juvenile (spat), regulated by complex interaction of neurotransmitters and neurohormones such as L-DOPA epinephrine (catecholamine). We recently suggested an N-Methyl-D-aspartate (NMDA) receptor pathway additional previously unknown regulator bivalve metamorphosis. To explore this theory further, we successful...

Norepinephrine synthesis was determined in the heart and adrenals of rabbits made hypertensive by complete denervation of the carotid sinuses and aortic arch. There was a 24% reduction of norepinephrine concentration in the left ventricle 3 weeks after denervation, despite evidence of enhanced synthesis as determined by three methods: (1) an 18% increase in apparent synthesis rates (from 0.76 t...

We measured a2-adrenoreceptor density as well as affinity for and sensitivity to agonist on intact platelets of normotensive and hypertensive subjects before and after physiological increases in plasma catecholamines. In normotensives, posture-induced rises in plasma catecholamines correlated with reduced C2-adrenoreceptor agonist affinity and fewer high affinity state receptors. Platelet aggre...

Aim: To describe a rare case of catecholamine induced polymorphic ventricular tachycardia.
 Presentation Case: Intermittent attacks Ventricular fibrillation and syncope.
 Summary: Catecholaminergic tachycardia (CPVT) is familial cardiac arrhythmia that associated with ryanodine receptor gene (RYR2) or calsequestrin 2 (CASQ2) mutation. It condition occurs in patients structurally norma...