This study was undertaken to evaluate the effect of pomegranate (Punica granatum, P.g.) juice on the oxidation state of the brain tissue of adult male albino rats and whether P.g. juice administration improves the activity of the antioxidant enzymes after carbon tetrachloride (CCl4) treatment as an oxidative stress agent. Rats were divided into four groups, Group I (control) was received intrap...

It is widely recognized that exposure to combinations or mixtures of chemicals may result in highly exaggerated toxicity even though the individual chemicals might not be toxic. Assessment of risk from exposure to combinations of chemicals requires the knowledge of the underlying mechanism(s). Dietary exposure to a nontoxic dose of chlordecone (CD; 10 ppm, 15 days) results in a 67-fold increase...

Background: Carbon tetrachloride (CCl4) is a critical hepatotoxicant causing liver injury and fibrosis via hepatic production of reactive oxygen species (ROS). Apigenin (APG) natural bioactive compound flavonoid antioxidant. We, therefore, evaluated whether APG could mitigate CCl4-mediated hepatotoxicity. Methods: Rats were randomly divided administered and/or CCl4 in Control group, + groups (A...

A rapid serial visual presentation (RSVP) technique was used to investigate the role of the nature of processing carried out on targets in the Lag-1 sparing phenomenon. Lag-1 sparing refers to a higher accuracy in the task associated with the 2nd target when the 2 targets are immediately successive in the RSVP stream relative to when there are 1 or 2 intervening items between the targets. In 5 ...

BACKGROUND Sonchus asper (SAME) is used as a folk medicine in hepatic disorders. In this study, the hepatoprotective effects of the methanol extract of SAME was evaluated against carbon tetrachloride (CCl4)-induced liver injuries in rats. METHODS To evaluate the hepatoprotective effects of SAME, 36 male Sprague-Dawley rats were equally divided into 6 groups. Rats of Group I (control) were giv...

Background: Liver fibrogenesis can lead to the development of cirrhosis and hepatocellular carcinoma. This study was designed to evaluate the hepatoprotective effect of curcumin on CCl4-induced fibrosis in rats and to assess its antioxidant and anti-inflammatory properties. Method: Rats were divided into four groups. Group 1 (n=10) was control vehicle, Group 2 (n=10); rats were injected with CC...

OBJECTIVE To evaluate the hepatoprotective and immunotherapeutic effects of aqueous extract of turmeric rhizome in CCl4 intoxicated Swiss albino mice. METHODS First group of mice (n=5) received CCl4 treatment at a dose of 0.5 mL/kg bw (i.p.) for 7 days. Second group was fed orally the aqueous extract of turmeric at a dose of 50 mg/kg bw for 15 days. The third group was given both the turmeric...

1. Epidermal growth factor (EGF) is known to protect the gastrointestinal tract against various noxious agents. Its potential value in preventing/ treating hepatic injury is, however, largely unexplored. We therefore examined whether EGF could influence CCl4-induced hepatic injury. 2. Female Sprague-Dawley rats (8 per group) received saline or recombinant EGF (500 or 750 micrograms/kg, intraper...

The present study was undertaken to investigate the hepatoprotective effect of pantothenic acid on CCl4-induced liver damage. Male Wistar rats were orally treated with pantothenic acid (0.005, 0.01, 0.025, 0.05 and 0.1 g/kg) daily, with administration of CCl4 (1 mL/kg, 50 % CCl4 in olive oil) twice a week for 28 days. The effect of pantothenic acid on serum markers (alanine aminotransferase, as...

This study investigated an application of TiO2 photocatalyst sensitized with tris(4,4'-dicarboxy-2,2'-bipyridyl)ruthenium-(II) complex to CCl4 degradation under visible light irradiation. By injecting electrons from the photoexcited sensitizer to the conduction band, the sensitized TiO2 degraded CCl4 under the irradiation of lambda > 420 nm. The quantum yield of CCl4 dechlorination was about 10...