Visceral metastasis is widely considered a prognostic factor for overall survival of men with metastatic castration-sensitive prostate cancer (mCSPC) and has been historically managed androgen deprivation therapy (ADT). More recently, this therapeutic scenario enriched by the possibility to integrate ADT chemotherapy or novel androgen-signaling–targeted inhibitors. In order define effect chemot...

Glycogen synthase kinase-3 beta (GSK-3β) is implicated in abnormal hyperphosphorylation of the tau protein and its inhibitors may be a promising therapeutic approach for treating Alzheimer’s disease. Here, series C-glycosylfavone derivatives as GSK-3β was selected to perform two-dimensional quantitative structure activity relationship (2D-QSAR) method docking analysis. The 2D-QSAR model generat...

The US National Cancer Institute estimates that cardiotoxicity (CTX) from target therapy refers mostly to four groups of drugs: epidermal growth factor receptor 2 inhibitors, angiogenic inhibitors, directed Abelson murine leukemia viral oncogene homolog inhibitors, and proteasome inhibitors. The main cardiotoxic side-effects related to antiepidermal growth factor receptor 2 therapy are left ven...

EGFR (epidermal growth factor receptor) is activated through changes in expression or mutations in a number of tumors and is a driving force in cancer progression. EGFR is targeted by numerous inhibitors, including chimeric antibodies targeting the extracellular domain and small molecule kinase domain inhibitors. The kinase domain inhibitors are particularly active against mutant forms of the r...

The article presents a clinical case illustrating the effectiveness of abemaciclib in combination with anastrozole metastatic estrogen receptor-positive HER2/neu-negative breast cancer (BC). CDK4/6 inhibitors have changed paradigm treatment patients hormone-positive HER2 BC. Thanks to ability palbociclib, ribociclib and delay overcome resistance endocrine therapy, not only newly diagnosed disea...

Background: Heart failure with reduced ejection fraction (HFrEF) is a syndrome consisting of typical symptoms and/or signs heart (HF) due to left ventricular systolic dysfunction (ejection ≤40%) caused by various underlying cardiac diseases. We report conventional and recently established pharmacologic nonpharmacologic treatments HFrEF in this review article.Current Concepts: So far, have been ...

Treatment for metastatic HER2-negative breast cancer is becoming increasingly individualized as more of the tumor landscape described and drugs are developed to target its pathways. Survival can be prolonged by CDK4/6 inhibitors in patients with hormone receptor–positive tumors immunotherapy those triple-negative disease. In BRCA1/2 mutations, PARP delay disease progression. Antibody–drug conju...

The importance of B-cell activation and immune complex-mediated Fc-receptor activation in the pathogenesis of immunologically mediated glomerulonephritis has long been recognized. The two nonreceptor tyrosine kinases, spleen tyrosine kinase (Syk) and Bruton's tyrosine kinase (Btk), are primarily expressed by hematopoietic cells, and participate in B-cell-receptor- and Fc-receptor-mediated activ...

Esophageal cancer is a formidable challenge in the realm of treatment. Conventional methods such as surgery, chemotherapy, and immunotherapy have demonstrated limited success rates managing this disease. In response, targeted drug therapies emerged promising strategy to improve outcomes for patients. These aim disrupt specific pathways involved growth development esophageal cells. This review e...