Extracorporeal photochemotherapy (ECP) has been associated with clinical improvement in several patients with acute and chronic graft-versus-host disease (cGVHD) after allogeneic bone marrow transplantation, but the mechanism of action is unknown. This study tested the hypothesis that in patients with cGVHD, ECP modulates alloreactivity by affecting activated lymphocyte populations or by alteri...

Cell-mediated immunity is considered to be normal in Darier's Disease (DD), an inherited skin disorder complicated by skin infections. To date, there are no investigations on the local inflammatory infiltrate in DD skin lesions. In this immunohistochemical study we characterized and quantified it, making comparisons with two other inflammatory skin disorders, that is, pemphigus vulgaris (PV) an...

Chemotherapy has been dominating the field of cancer treatment for a long time, however, its limitations have revealed over time. Therefore, several antigen proteins and chimeric receptorT cells (CAR-T) involved in immunotherapy acute lymphoblastic leukemia (ALL) myeloid (AML) introduced. This paper provides details on mechanisms, implemented investigations, drawbacks ALL AML. Current studies s...

Differentiating cutaneous diseases that mimic each other clinically and histopathologically can at times be a challenging task for the dermatopathologist. At same time, differentiation of entities with overlapping features may crucial patient management. Although not seen in normal skin, plasmacytoid dendritic cells usually infiltrate skin several infectious, inflammatory/autoimmune neoplastic ...

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive hematological malignancy that is derived from the precursors of plasmacytoid dendritic cells. Although BPDCN typically manifests in the skin, it can also evolve into a leukemic form or be complicated by acute myeloid leukemia, and some cases involve preceding myelodysplastic syndrome. We report the case of a 73...