the prevalence of celiac disease in apparently healthy iranian blood donors. should we screen healthy population?

Celiac disease is an autoimmune disorder of the small bowel, classically associated with diarrhea, abdominal pain, and malabsorption. The diagnosis of celiac disease is made when there are compatible clinical features, supportive serologic markers, representative histology from the small bowel, and response to a gluten-free diet. Histologic findings associated with celiac disease include intrae...

BACKGROUND The presence of HLA haplotype DR3-DQ2 or DR4-DQ8 is associated with an increased risk of celiac disease. In addition, nearly all children with celiac disease have serum antibodies against tissue transglutaminase (tTG). METHODS We studied 6403 children with HLA haplotype DR3-DQ2 or DR4-DQ8 prospectively from birth in the United States, Finland, Germany, and Sweden. The primary end p...

BACKGROUND Although it is known that first degree relatives of celiac patients have an increased risk for celiac disease few studies are available on its incidence. We investigated the incidence of serologic conversion and of new cases of celiac disease among first degree relatives with negative results at a first screening. METHODS From a total of 634 first degree relatives of 186 biopsy-pro...

Importance The prevalence of gluten-related disorders is rising, and increasing numbers of individuals are empirically trying a gluten-free diet for a variety of signs and symptoms. This review aims to present current evidence regarding screening, diagnosis, and treatment for celiac disease and nonceliac gluten sensitivity. Observations Celiac disease is a gluten-induced immune-mediated enter...

With the diagnosis of celiac disease rising in the past decade and with increased public awareness, team physicians are faced with both managing and diagnosing athletes with celiac disease. Sports medicine physicians need to recognize that celiac disease can present with a number of different symptoms and, therefore, should consider celiac disease as part of their differential in evaluating ath...

BACKGROUND It has been suggested that high titres of tTG are associated with elevated positive predictive values (PPV) for celiac disease. However, the PPV of a strongly positive tTG will depend on the celiac disease prevalence in the different risk groups of the disease AIMS To assess the PPV of a strongly positive tTG for celiac disease. In addition, to calculate the post-test probability f...

OBJECTIVE To evaluate changes in the clinical presentation of celiac disease in southeastern Wisconsin. DESIGN Retrospective medical record review. SETTING Clinical specialty practice in pediatric gastroenterology. Patients The medical records of all patients diagnosed with celiac disease at the Children's Hospital of Wisconsin between 1986 and 2003 were reviewed. Data extracted from the me...

OBJECTIVE The present study was designed to compare the bone mineral density of children and adolescents with celiac disease to the bone mineral density of controls, and to evaluate laboratory analysis of calcium metabolism of celiac disease patients. METHODS Thirty celiac disease patients (17 children, 13 adolescents), on a gluten-free diet, and 23 healthy subjects were studied. Tests of bon...

BACKGROUND Although serological tests are useful for identifying celiac disease, it is well established that a minority of celiacs are seronegative. AIM To define the prevalence and features of seronegative compared to seropositive celiac disease, and to establish whether celiac disease is a common cause of seronegative villous atrophy. METHODS Starting from 810 celiac disease diagnoses, se...