Celiac disease is an inflammatory disorder of the small intestine, triggered by the ingestion of gluten proteins contained in wheat, barley or rye, in genetically susceptible individuals. This disorder is considered to be mainly mediated by cellular immunity and restricted to the human leucocyte antigen-DQ presentation of gluten-derived toxic peptides to T-cells. Moreover, the involvement of in...

BACKGROUND & AIMS Early nutrition may affect the risk of celiac disease. We investigated whether amount of gluten in diet until 2 years of age increases risk for celiac disease. METHODS We performed a 1-to-3 nested case-control study of 146 cases, resulting in 436 case-control pairs matched for sex, birth year, and HLA genotype generated from Swedish children at genetic risk for celiac diseas...

Knowing whether or not a food contains gluten is vital for the growing number of individuals with celiac disease and non-celiac gluten sensitivity. Questions have recently been raised about whether beef from conventionally-raised, grain-finished cattle may contain gluten. To date, basic principles of ruminant digestion have been cited in support of the prevailing expert opinion that beef is inh...

c i e b Since the association between gluten intake and celiac disease (CD) was established by Dicke1 during World War II, our understanding of the pathophysiology of gluten-sensitive enteropathy has markedly increased, especially with the resources of molecular research. However, although it is clear that gluten intake causes enteropathy and extraintestinal disease in genetically-susceptible i...

Celiac crisis presents as severe acute diarrhea with life-threatening metabolic derangement in a patient with celiac disease. We report a 30-year-old lady who was admitted with one-month history of worsening small bowel-type diarrhea. She developed acute quadriparesis due to refractory hypokalemia. Celiac disease was diagnosed on the basis of positive serology and histological features. She imp...

CONTEXT The ingestion of gluten is responsible for the symptoms of Celiac disease, but other environmental factors can also influence. Strains of the Bifidobacterium genus have been shown to afford protection against the inflammatory response and mucosal damage caused by gliadin peptides in vitro. OBJECTIVES This study was designed to compare the concentration of fecal bifidobacteria and pH o...

Importance Celiac disease is caused by an immune response in persons who are genetically susceptible to dietary gluten, a protein complex found in wheat, rye, and barley. Ingestion of gluten by persons with celiac disease causes immune-mediated inflammatory damage to the small intestine. Objective To issue a new US Preventive Services Task Force (USPSTF) recommendation on screening for celiac...

Celiac disease has been associated with selective IgA immunoglobulin deficiency. A celiac disease cohort of 234 biopsy-defined adults (including 73 males and 161 females) from a 30-year period from 1982 to 2011 was reviewed. A total of 7 with selective IgA immunoglobulin deficiency were noted, or about 3%. All were female with an initial positive biopsy for untreated celiac disease. All had cha...

Celiac sprue is a disorder characterized by the symptoms of malabsorption and an abnormal small bowel histology, which is due to the patient's intolerance to gluten. Gluten is a protein found in wheat and wheat products. The typical symptoms of malabsorption include weight loss, abdominal distention, bloating, diarrhea and steatorrhea. However, the severity of the disease varies greatly among t...

Celiac disease is a genetically inherited autoimmune disorder triggered by dietary gluten that damages the intestinal villi in the proximal small intestine. Once tall and slender, the damaged villi become blunted or completely flattened. As a result, the available absorptive area is reduced considerably, which causes malabsorption. This condition affects both children and adults. In young child...