Adult T-cell leukemia/lymphoma (ATL) is a highly aggressive disease in which the Jak2/Stat5 pathway is constitutively activated. This study found that AZ960, a novel inhibitor of Jak2 kinase, effectively induced growth arrest and apoptosis of human T-cell lymphotropic virus type 1, HTLV-1-infected T cells (MT-1 and MT-2) in parallel with downregulation of the phosphorylated forms of Jak2 and Bc...

City-dwelling children from Kenya who were infected with human immunodeficiency virus type 1 (HIV-1) were tested for coinfection with cytomegalovirus (CMV), human T cell lymphotropic viruses 1 and 2, Kaposi sarcoma-associated herpesvirus (KSHV), or hepatitis B, C, and G viruses. All children were found to be coinfected with CMV, whereas 5% had hepatitis G virus coinfection and 15% had KSHV coin...

SIR—Casseb [1] hypothesizes that human T-cell lymphotropic virus type I (HTLV-I) is “more clever” than human immunodeficiency virus type 1 (HIV-1). One of his reasons is that HTLV-I, unlike HIV-1, has “an exceptionally low capability for causing death in the host.” “Cleverness” is not a biological concept but rather an anthropomorphism. Casseb probably is referring to the biological success of ...

Some viruses preferentially infect restricted subpopulations of lymphocytes . The pathogenesis of the diseases induced by these lymphotropic viruses is determined at least in part by this selectivity of infection . Herpesvirus saimiri, a lymphotropic herpesvirus that causes no apparent disease in its natural host Saimiri sciureus (squirrel monkey), induces a fulminant lymphoproliferative syndro...

S100-positive T lymphocytes account for less than 3% of peripheral blood T cells. Rare cases of S100-positive T-cell lymphoma have been previously described. We report four such cases of S100-positive T-cell chronic lymphoproliferative disease. In all cases, hepatosplenomegaly was observed, without prominent lymphadenopathy. Central nervous system (CNS) involvement by the leukemic cells was sug...

Two cases of squamous carcinoma of the anus in white homosexual men aged 36 and 47 years are reported, each with a short history of rapidly enlarging perianal lesions. Immunological studies showed that both men had pronounced T helper lymphocyte depletion, and antibody to human T cell lymphotropic virus type III (HTLV-III) was detected in both patients. In addition one patient had a long histor...