The nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows is an active organelle, constantly sensing surrounding environment and translating extracellular mechanical inputs into intracellular signaling. nuclear envelope large membrane reservoir which serves buffer for it unfolds without its tension. In contra...

Cell migration is fundamental to normal CNS development. Radial migration, along radial glial fibers, has been the principal pathway studied, however, nonradial or tangential cell migration has increasingly been identified at all levels of the CNS. Receptors, cell adhesion molecules, and extracellular matrix molecules have all been shown to participate in radial cell migration. In contrast, the...