Two synthetic aziridinomitosenes (AZMs), Me-AZM and H-AZM, structurally related to mitomycin C (MC) were evaluated for their anticancer activity against six cancer cell lines (HeLa, Jurkat, T47D, HepG2, HL-60, and HuT-78) and tested for their DNA-modifying abilities in Jurkat cells. Cytotoxicity assays showed that Me-AZM is up to 72-fold and 520-fold more potent than MC and H-AZM, respectively....

Magnesium deficiency (MgD) has been shown to impact numerous biological processes at the cellular and molecular levels. In the present review, we discuss the relationship between MgD and oxidative stress (OS). MgD is accompanied by increased levels of OS markers such as lipid, protein and DNA oxidative modification products. Additionally, a relationship was detected between MgD and a weakened a...

aim : in this study, we was tried to prepare a nano compound with a new way in functionalization as anti gastric cancer candidate. background : functionalization of nanotubes is a useful route for modification of their biologic properties. (3-oxoindolin-2-ylidene) urea is a chemical compound that made of isatin and urea that can be useful in cancer study. patients and methods : mwnt-cooh was fu...

Background Despite the long history associated with varicocele, it remains one of the most controversial issues in the field of Andrology. The main base of this is our current understanding of the pathophysiology of this disease. This has hampered treatment and management of varicocele, especially regarding why, when and to whom varicocelectomy should be applied. The main molecular pathology of...

the identification of multipotential mesenchymal stem cells (mscs) derived from adult human tissues such as bone marrow and connective tissues has provided exciting prospects for cell-based tissue engineering and regeneration. this review article focuses on the biology of mscs, their differentiation potentials in vitro and in vivo, and their application in tissue engineering. our current unders...

Redundant functions maintained from single to multi-cellular organisms have made Saccharomyces cerevisiae an important model for the analysis of conserved com-plex cellular processes. Yeast has been especially useful in understanding the regulation and function of the essential molecular chaperone, Heat Shock Protein 90 (Hsp90). Research focused on Hsp90 has determined that it is highly regulat...