Increasing evidence has involved the cerebellum in functions beyond the sphere of motor control. In the present article, we review evidence that involves the cerebellum in addictive behaviour. We aimed on molecular and cellular targets in the cerebellum where addictive drugs can act and induce mechanisms of neuroplasticity that may contribute to the development of an addictive pattern of behavi...

Functional magnetic resonance imaging was used to test whether odorants induce activation in the cerebellum of the human. The odorants vanillin and propionic acid both induced significant activation, primarily in the posterior lateral hemispheres. Activation was concentration-dependent, greater after stimulation with higher concentration odorants. By contrast, the action of sniffing nonodorized...

The cerebellum has been considered for a long time to play a role solely in motor coordination. However, studies over the past two decades have shown that the cerebellum also plays a key role in many motor, cognitive, and emotional processes. In addition, studies have also shown that the cerebellum is implicated in many psychiatric disorders including attention deficit hyperactivity disorder, a...

Using an event-related fMRI procedure, we investigated the role of the human cerebellum in sequential finger movements. Subjects performed a delayed sequential finger movement task in which an instructive cue preceded the imperative signal by 16.5 s. Bilateral activation was observed in the cerebellum following both the cue and imperative signals. The activated regions overlapped within the cer...

In the developing cerebellum, the medio-lateral compartmentalization of the adult cerebellum is preceded by the transient expression of factors which divide the cortex into similar parasagittal stripes. Here we report that COUP-TF2, an orphan member of the nuclear receptor family which suppresses RA actions by forming heterodimers with RXR, shows a pattern of sagittal bands in developing mouse ...

Recent studies have indicated the additional role of cerebellum beyond motor coordination non-motor and socio-cognitive tasks. Exploration of cerebellar roles in timing and plasticity have been attributed specific roles in neurological conditions such as ataxia, severe disorders such as Parkinson’s and epilepsy. Cerebellar dysfunctions elaborate the need of research on cerebellar circuitry and ...

The aim of our investigation was to demonstrate the wide distribution of glutamate N-methyl-Daspartate receptors (NMDA R), particularly the not-widely investigated 2A and 2B subunits, in the human adult cerebellum and hippocampus. Specimens of human hippocampus and cerebellum were obtained at the time of autopsy from two male individuals, aged 24 and 48 years, with no obvious brain injury. The ...

Abstract Oscillations play a pivotal role in shaping cerebellar local activity and its communication with neocortical areas involved learning motor skills. Previous studies have emphasized the presence potentially important of beta (15-30 Hz) oscillations such processes. Yet, distribution causal nature interregional synchronization patterns at frequencies remain elusive. The present study aims ...

A functional characterization of the cerebellum centers on the hypothesis that this structure is essential for the representation of temporal relationships in the subsecond range. This hypothesis is supported by evidence involving a wide range of methods, including lesion studies, neuroimaging, and, to a limited extent, stimulation studies with transcranial magnetic stimulation. The extent of t...