Oral mouthwashes decrease the infectivity of several respiratory viruses including SARS-CoV-2. However, precise agents with antiviral activity in these oral rinses and their exact mechanism action remain unknown. Here we show that cetylpyridinium chloride (CPC), a quaternary ammonium compound many mouthwashes, reduces SARS-CoV-2 by inhibiting viral fusion step target cells after disrupting inte...

The aim of this preliminary study was to verify the antibacterial potential of cetylpyridinium chloride (CPC) in root canals infected by Enterococcus faecalis. Forty human maxillary anterior teeth were prepared and inoculated with E. faecalis for 60 days. The teeth were randomly assigned to the following groups: 1: Root canal preparation (RCP) + 0.1% CPC with positive-pressure irrigation (PPI, ...

The purpose of this study was to investigate the influence of anion size and the contribution of the epithelial sodium channel (ENaC) and the transient receptor potential vanilloid-1 (TRPV1) channel on sodium-taste responses in rat chorda tympani (CT) neurons. We recorded multiunit responses from the severed CT nerve and single-cell responses from intact, narrowly tuned and broadly tuned, salt-...

In this work, nanopowders (NP) Co(OH)2 were obtained by chemical precipitation from aqueous solutions of cobalt nitrate Co(NO3)2 and alkali NaOH (10 wt. %) using surfactants: sodium dodecyl sulfate (SDS) cetylpyridinium chloride (CPC) (0.1 %). It was shown that NP with 0.1% SDS is the best quality product, since its dispersion increases more than 2 times compared to samples CPC without surfacta...

A novel method with quaternary ammonium salts as internal additives has been applied to the mass scale calibration of time-of-flight secondary ion mass spectrometry (TOF-SIMS). Five kinds of quaternary ammonium salts, octyltrimethylammonium bromide (C8TMA), tetradecyltrimethylammonium chloride (C14TMA), octadecytrimethylammonium chloride (C18TMA), cetylpyridinium chloride (CPC) and benzyldimeth...

The present research aims to determine the antimicrobial efficacy of mouthwashes based on cetylpyridinium chloride (CPC), before aerosol producing dental procedures. A data search was performed during August 2021 in five databases MEDLINE (PubMed), SCOPUS, SCIELO, Cochrane Central Register Controlled Trials (CENTRAL) and Google Scholar. Randomized clinical trials (RCTs) were included PICO quest...