This paper describes a vehicle detection system fusing radar and vision data. Radar data are used to locate areas of interest on images. Vehicle search in these areas is based on vertical symmetry. All vehicles found in different image areas are mixed together and a series of filters are applied in order to delete false positives. The algorithm analyzes images on a frame by frame basis, without...

A popular framework for false discovery control is the random effects model in which the null hypotheses are assumed to be independent. This paper generalizes the random effects model to a conditional dependence model which allows dependence between null hypotheses. The dependence can be useful to characterize the spatial structure of the null hypotheses. Asymptotic properties of false discover...

Water is often found to mediate interactions between a ligand and a protein. It can play a significant role in orientating the ligand within a binding pocket and contribute to the free energy of binding. It would thus be extremely useful to be able to accurately predict the position and orientation of water molecules within a binding pocket. Recently, we developed the WaterDock protocol that wa...

The Iberian Peninsula has been the focus of attention of numerous studies dealing with mitochondrial DNA (mtDNA) variation, most of them targeting the control region segment. In the present study we sequenced the control region of 3,024 Spanish individuals from areas where available data were still limited. We also compiled mtDNA haplotypes from the literature involving 4,588 sequences and 28 p...

Consider the standard multiple testing problem where many hypotheses are to be tested, each hypothesis is associated with a test statistic, and large test statistics provide evidence against the null hypotheses. One proposal to provide probabilistic control of Type-I errors is the use of procedures ensuring that the expected number of false positives does not exceed a user-supplied threshold. A...

Activity in populations of neurons is essential for cortical function including signaling of information and signal transport. Previous methods have made advances in recording activity from many neurons but have both technical and analytical limitations. Here we present an optical method, dithered random-access functional calcium imaging, to record somatic calcium signals from up to 100 neurons...

As we await the release of the forthcoming DSM-5 and the development of the ICD-11, issues pertaining to the classification and diagnosis of mental disorders have become more prominent. With criticism and anticipation abounding, pertaining to the modification, or lack of, of the diagnostic criteria of mental disorders, have we become overly focused upon the diagnostic criteria to the detriment ...

The yeast three-hybrid system presents a valuable tool for detecting and analyzing RNA-protein interactions in vivo. A major drawback of the use of such a transcriptional reporter-based assay in a library screen is the frequent occurrence of false-positive results due to bait RNA-independent activation of the reporter gene. To minimize the isolation of false positives in three-hybrid library sc...

Identification of functional sets of genes associated with conditions of interest from omics data was first reported in 1999, and since, a plethora of enrichment methods were published for systematic analysis of gene sets collections including Gene Ontology and biological pathways. Despite their widespread usage in reducing the complexity of omics experiment results, their performance is poorly...