Abstract Coronavirus disease 2019 (COVID-19) continues to spread across the globe, with numerous clinical trials underway seeking develop and test effective COVID-19 therapies, including remdesivir. Several ongoing studies have reported hydroxychloroquine-induced cardiotoxicity, development of torsade de pointes (TdP). Meanwhile, human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC...

BACKGROUND The usage of nursing home (NH) services is a marker of frailty among older adults. Although the Centers for Medicare & Medicaid Services (CMS) revised the Medical Evidence Report Form CMS-2728 in 2005 to include data collection on NH institutionalization, the validity of this item has not been reported. METHODS There were 27,913 patients ≥ 75 years of age with incident end-stage re...

This note gathers the existing information on the parameters of the CMS silicon microstrip detectors, in order to compute the signal–to–noise ratio for different configurations. Both signal and noise are computed analytically, starting from laboratory measurements of the characteristic impedances of the detectors. Results are presented for a 50 m strip pitch detector, read out every strip and e...

Human embryonic stem (hES) cells can differentiate in vitro, forming embryoid bodies (EBs) composed of derivatives of all three embryonic germ layers. Spontaneously contracting outgrowths from these EBs contain cardiomyocytes (CMs); however, the types of human CMs and their functional properties are unknown. This study characterizes the contractions and action potentials (APs) from beating EB o...

In climate change research, future scenarios of greenhouse gas and air pollutant emissions generated by integrated assessment models (IAMs) are used in climate models (CMs) and earth system models to analyze future interactions and feedback between human activities and climate. However, the spatial resolutions of IAMs and CMs differ. IAMs usually disaggregate the world into 10-30 aggregated reg...

In this paper, the characteristic equations of the E mn and Ex mn modes of the dielectric rectangular waveguide have been derived using the mode matching technique. No assumptions have been taken in the derivations which have been straight forwardly done. Two ratios have been introduced in the characteristic equations and the new set of characteristic equations thus obtained are then plotted an...

The characteristic methods are known to be very efficient for convection-diffusion problems including the Navier-Stokes equations. Convergence is established when the integrals are evaluated exactly, otherwise there are even cases where divergence has been shown to happen. The family of methods studied here applies Lagrangian convection to the gradients and the function as in Yabe[?]; the metho...

BACKGROUND Human induced pluripotent stem cells (iPSCs) are attractive candidates for therapeutic use, with the potential to replace deficient cells and to improve functional recovery in injury or disease settings. Here, we test the hypothesis that human iPSC-derived cardiomyocytes (iPSC-CMs) can secrete cytokines as a molecular basis to attenuate adverse cardiac remodeling after myocardial inf...