Carboxypeptidase M (CPM) targets the basic amino acids arginine and lysine present at the C-terminus of peptides or proteins. CPM is thought to be involved in inflammatory processes. This is corroborated by CPM-mediated trimming and modulation of inflammatory factors, and expression of the protease in inflammatory environments. Since the function of CPM in and beyond inflammation remains mainly...

OBJECTIVES Normal efficiency of exercise-induced hypoalgesia (EIH) has been demonstrated in people with knee osteoarthritis (OA), while recent evidence suggests that EIH may be associated with features of pain sensitization such as abnormal conditioned pain modulation (CPM). The aim of this study was to investigate whether people with knee OA with abnormal CPM have dysfunctional EIH compared wi...

Abstract The DD-CPM software library provides a set of tools for the discretization and solution problems arising from closest point method (CPM) partial differential equations on surfaces. solvers are built top well-known PETSc framework, supplemented by custom domain decomposition (DD) preconditioners specific to CPM. These fully compatible with distributed memory parallelism through MPI. Thi...

This study defines a methodology to compute unitary costs for freight transportation modes. The main objective was to gather relevant costs data to support the formulation and evaluation of railway, road, pipelines and port projects. This article will concentrate on the following steps: Compilation and analysis of relevant modal cost studies, Methodological adjustments to make cost figures comp...

Currently, there are many ways to save energy for the switch such as change the operating modes to low power modes: SLEEP PORT and SLEEP SWITCH when there is no traffic flowing through the Ethernet ports. The switch will be waked up to normal modes when traffic flows pass through it. However, the changes of the modes of the OpenFlow Switch will create DELAY-TIME. If we know DELAY-TIME, then we ...

The operation principle of resonant channel add–drop filters based on degenerate symmetric and antisymmetric standing-wave modes has been described elsewhere using group theoretical arguments. In this paper, the analysis is carried out using coupling of modes in time. A possible implementation of such a filter is a four-port system utilizing a pair of identical single-mode standing wave resonat...

Effective pain management is crucial for patient recovery after total knee arthroplasty (TKA). Biofeedback therapy, which encourages relaxation and helps alleviate various conditions associated with stress, may help to decrease postoperative pain in patients undergoing TKA. A quasi- experimental design was used to investigate the efficacy of a biofeedback relaxation intervention in reducing pai...

We report a case in whom slow correction of hyponatremia (5 mmol/day for 3 days) induced central pontine myelinolysis (CPM). After the diagnosis was confirmed by imaging, we started to relower serum Na that completely recovered the sign and symptoms of CPM. Rapid correction of serum sodium is known to be associated with CPM. However, it may occur even after slow correction of hyponatremia. Curr...

BACKGROUND Parental behaviors, emotions, and cognitions are known to influence children's response to pain. However, prior work has not tested the association between maternal psychological factors and children's responses to a conditioned pain modulation (CPM) task. CPM refers to the reduction in perceived pain intensity for a test stimulus following application of a conditioning stimulus to a...