Balanced levels of histones are crucial for chromosome stability, and one major component of this control regulates histone mRNA amounts. The Saccharomyces cerevisiae poly(A) polymerases Trf4 and Trf5 are involved in a quality control mechanism that mediates polyadenylation and consequent degradation of various RNA species by the nuclear exosome. None of the known RNA targets, however, explains...

Women with pathogenic/likely pathogenic (P/LP) variants in inherited breast cancer genes are more likely to develop their lifetime. NCCN guidelines recommend a discussion about contralateral risk reduction mastectomy (RRM) for BRCA1/2 and PALB2 carriers, however there is insufficient evidence uniformly RRM among women solely based on P/LP variant CHEK2 or ATM. Using the Inherited Cancer Registr...