background : tongue cancer is one of the most common cancers of the oral cavity, excluding lip, and the median age of the patients is approximately 60 years. methods : treatment results of a total of 110 patients with oral tongue cancer admitted to cancer institute of tehran university between1999-2003 were retrospectively analyzed. the patients were treated by surgery or radiotherapy or chemot...

Department for severe gastrointestinal bleeding. She had been diagnosed with IgAk multiple myeloma three years earlier and had been treated with both chemotherapy and radiotherapy (this latter for spinal cord compression by extramedullary myelomatous tissue). On admission, gastroscopy showed a bleeding gastric ulcer and blood cell counts were the following: Hb 4.2 g/dL, WBC 1.9310/L (differenti...

Mediastinal liposarcoma (ML) is a rare mesenchymal tumor, accounting for less than 1% of mediastinal tumors. They have a slow growth, so they may not give symptoms for a long time, until the tumor produces compression of close structures. The treatment of choice is surgery, which can be combined with chemo-radiotherapy. We present a case in which the diagnosis of a ML was made in a 30-year-old ...

Esophageal squamous cell carcinoma is a rather common cancer in northern Iran. Incidence of adenocarcinoma of esophagus has an increasing trend in Iran. Co-existence of both cancers in one patient is very rare. We report a middle age woman from northern Iran with a typical presentation of esophageal cancer, who was found to have a dual esophageal cancer. The disease was found in the advanced st...

Glioblastoma multiforme (GBM) remains the most aggressive and challenging brain tumour to treat. We report the first successful chemo-radiotherapy on patient derived treatment resistant GBM cells using a cisplatin-tethered gold nanosphere. After intracellular uptake, the nanosphere effects DNA damage which initiates caspase-mediated apoptosis in those cells. In the presence of radiation, both g...

I am most pleased to introduce you to the Winter 2008 issue of Advancing Ob/Gyn. As has become our tradition, inside you will find reports of recent clinical developments and research in progress at Yale Obstetrics, Gynecology & Reproductive Sciences. While we have many significant advances in our three mission areas of education, clinical care, and research, we have selected only those topics ...

BACKGROUND Glioma, including anaplastic astrocytoma and glioblastoma multiforme (GBM) are among the most commonly diagnosed malignant adult brain tumors. GBM is a highly invasive and angiogenic tumor, resulting in a 12 to 15 months median survival. The treatment of GBM is multimodal and includes surgical resection, followed by adjuvant radio-and chemotherapy. We have previously reported that sh...

Cancer stem cells (CSCs) play crucial roles in tumor progression, chemo- and radiotherapy resistance, and recurrence. Recent studies on CSCs have advanced understanding of molecular oncology and development of novel therapeutic strategies. This review article updates the hypothesis and paradigm of CSCs with a focus on major signaling pathways and effectors that regulate CSC apoptosis. Selective...

Primary leiomyosarcoma of breast is an extremely rare form of breast cancer with an unpredictable biological behavior, and usually presents as a slow growing mass in a middle to old age women. Surgical resection with wide margins is the main stay treatment followed by chemo radiotherapy. Long term follow up is done to look for local recurrence or distant metastasis. We are presenting a case of ...

Targeting the epithelial-to-mesenchymal transition (EMT) is emerging as a novel intervention against tumor progression and metastatic dissemination, as well as the resistance to chemo- and radiotherapy displayed by multiple carcinomas. We have recently developed an immunotherapeutic approach to target a major driver of EMT, the T-box transcription factor T (also known as brachyury). This therap...