OBJECTIVE To determine the prognostic factors for local recurrence of nodular hepatocellular carcinoma after segmental transarterial chemoembolization. MATERIALS AND METHODS Seventy-four nodular hepatocellular carcinoma tumors < or = 5 cm were retrospectively analyzed for local recurrence after segmental transarterial chemoembolization using follow-up CT images (median follow-up of 17 months,...

In many studies for chemoembolization of hepatocellular carcinoma, the Lipiodol emulsion preparation protocols, especially the mixing steps, were unclear or even unrevealed at all. However, doxorubicin (DOX) release may depend on the composition and volume ratio (Lipiodol to DOX solution) of a Lipiodol emulsion. Therefore, we conducted a preclinical study to compare in-vitro drug release and in...

Aim: The aims of this cohort study are, first, to describe the clinical and etiological profile and, second, to report treatment outcomes of patients with hepatocellular carcinoma presenting to a tertiary care hospital in the North of Portugal. Methods: Retrospective analysis of the electronic charts of 139 patients admitted in our institution between July 2008 and September 2012. Results: The ...

OBJECTIVE We wanted to introduce a new technique for superselective catheterization of arteries with preshaping of a micro-guide wire into a shepherd's hook form, and this is useful for superselection of small arteries branching at an acute angle from a large parent artery for the treatment of tumors and hemorrhages. MATERIALS AND METHODS We developed a superselective catheterization techniqu...

results survival at 1-year, 2-years, 3-years and 5-years was 73.2%, 45.4%, 33.2% and 14.9% respectively. procedure-related mortality was 1.4%. multivariate analysis showed lesion diameter, child-pugh classification, alcohol abuse, tumor response and afp prior tace as independent prognostic factors of survival. patients diagnosed during surveillance had significantly better survival rates compar...

PURPOSE In hepatocellular carcinoma patients with large or multinodal tumors, where curative treatment options are not feasible, transarterial therapies play a major role. Transarterial chemoembolization (TACE) with drug-eluting beads (DEB-TACE) is a promising new approach due to higher intratumoral and lower systemic concentration of the chemotherapeutic agent compared to conventional TACE (cT...