It is clear from large clinical studies that selected chemokine receptors are often up-regulated in a large number of common human cancers, including those of the breast, lung, prostate, colon, and melanoma. Chemokine receptors and their corresponding chemokine ligands have been demonstrated to play a number of nonredundant roles in cancer metastasis to vital organs as well as regional lymph no...

background and objectives: alterations in cxcl10 (a th1 chemokine) expression have been associated with various diseases. the aim of this study was to evaluate the serum cxcl10 levels in h. pylori -infected patients with peptic ulcer (pu), h. pylori -infected asymptomatic (as) subjects and healthy h. pylori -negative subjects, and also to determine its association with bacterial virulence facto...

Motoring to a signaling check-up T he Smad2 signaling protein is shuttled back to the membrane to check up on its receptor, according to Julie Batut, Michael Howell and Caroline Hill (Cancer Research UK, London). The check-ups ensure that intracellular signaling accurately refl ects the activation status of the membrane-bound receptor. Smad proteins are phosphorylated by and act downstream of T...

Chemokines (chemotactic cytokines) comprise a large family of proteins that recruit and activate leukocytes, giving chemokines a major role in both immune response and inflammation-related diseases. The poxvirus-encoded viral CC chemokine inhibitor (vCCI) binds to many CC chemokines with high affinity, acting as a potent inhibitor of chemokine action. We have used heteronuclear multidimensional...

Dendritic cells initiate immune responses by ferrying antigen from the tissues to the lymphoid organs for presentation to lymphocytes. Little is known about the molecular mechanisms underlying this migratory behavior. We have identified a chemokine receptor which appears to be selectively expressed in human dendritic cells derived from CD34+ cord blood precursors, but not in dendritic cells der...

We have interrogated a 12-chemokine gene expression signature (GES) on genomic arrays of 14,492 distinct solid tumors and show broad distribution across different histologies. We hypothesized that this 12-chemokine GES might accurately predict a unique intratumoral immune reaction in stage IV (non-locoregional) melanoma metastases. The 12-chemokine GES predicted the presence of unique, lymph no...

AIM To investigate the association between the quantity of gastric chemokine mRNA expression, severity of gastritis, and cagA positivity in Helicobacter pylori associated gastritis. METHODS In 83 dyspeptic patients, antral and corpus biopsies were taken for semiquantitative reverse transcription polymerase chain reaction (RT-PCR) and histological grading of gastritis. Gastritis was evaluated ...