The metabolism of an organism is regulated at the cellular level, yet is strongly influenced by its environment. The precise metabolomic study of living organisms is currently hampered by measurement sensitivity: most metabolomic measurement techniques involve some compromise, in that averaging is performed over a volume significantly larger than a single cell, or require invasion of the organi...

Vibrational spectroscopy is an attractive modality for the analysis of biological samples, providing a complete non-invasive acquisition of the biochemical fingerprint of the sample. It has been demonstrated that this data provides the means to assay multiple functional responses of a biological system at a spatial resolution as low as a micron within the sample. As the interaction of ionizing ...

Vibrational spectroscopic techniques have advantages over conventional microbiological approaches towards identification & detection of pathogens. Since unique spectral fingerprint is obtained, one can identify very closely related bacteria using such methods. In this study Raman microspectroscopy in combination with chemometric method has been used to classify four strains of E. coli (two path...

Diphenhydramine HCl, benzonatate, guaifenesin and phenylephrine HCl are coformulated together in Bronchofree TM capsule in the ratio of 2.5:10:10:1 respectively. Literature review showed only one reported HPLC method for this mixture. Simultaneous chemometricassisted spectrophotometric analysis of the multi-component dosage form has been carried out using two chemometric methods. These methods ...