Background Compared to intrathecal methotrexate (IT MTX), triple intrathecal therapy (TIT) has shown promising results in decr...

Background: Lumbar puncture (LP) and bone marrow aspiration or biopsy in pediatric patients with hematological diseases is often repeated at regular intervals. These procedures are painful and unpleasant and bring a lot of stress for the children and their families. This study aimed to compare the effectiveness of two drug combinations of propofol-ketamine and propofol-remifentanil in children ...

backgroundfor using of complementary and alternative medicine methods (cam) in the leukemia pediatrics than other types of cancer, we have two great challenges; first challenge is their safety and risks and second challenge is study gaps in this field. regarding to these challenges, this study is a narrative review of some cam methods in the leukemia pediatrics from the perspective of their saf...

introduction: oral candidosis is among the find-ings of acute leukemia. the aim of this study was to evaluate the changes in the intensity of c.albicans, before treatment and at the induc-tion phase. materials and methods: twelve patients with acute lymphoblastic leukemia (all) aged 2-14 years enrolled in study. whole saliva samples were obtained and cultured to determine the mean count of c.al...

Background: The pharmacogenetic-oriented approach reduces the toxicity and increases the safety of chemotherapeutic agents. 6-mercaptopurin (6-MP) metabolizing enzymes such as thiopurine S-methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) contribute to variable responses and adverse effects among leukemia patients treated with 6-MP. The aim of our study was to identify th...

Introduction. The treatment outcome of adolescents and young adults with acute lymphoblastic leukemia is much poorer in contrast to pediatric patients. By changing the concept for patients who are leukemia, especially use regimens, significant improvement survival has been made (current 5-year rate goes up 70%). Contributing factors different outcomes between children leukemia. Beside differenc...

abstract background: childhood leukemia, the most common type of cancer in children and teens, is a cancer of the white blood cells. as antioxidants can promote immune system against all types of cancer, the aim of this study was to explore the metabolic regulation and anti-oxidative effect of sesquiterpen-rich extract of ferula asafoetida (fa) on children with leukemia. materials and methods: ...

Background: Vincristine polyneuropathy is a major neurotoxic complication of treatment for acute lymphoblastic leukemia in children. A close relationship between genetic variants candidate genes associated with the vincristine neurotoxicity various ethnic groups has been proposed. Therefore, identification risk factors underlying predisposition to could allow development effective tools prevent...