hydrogel based metronidazole bioadhesive tablet (hmbt) was prepared as a novel vaginal delivery system to achieve controlled release of drug from the tablet for vaginal candidiasis. the highly swollen hydrogel were prepared by dissolving chitosan in acetic acid solution containing drug, followed by neutralisation with sodium hydroxide and characterized by sem, dsc and ft-ir and evaluated for % ...

Hydrogel-based wound dressings provide a cooling sensation, a moist environment, and act as a barrier to microbes for wounds. In this study, a series of soft, flexible, porous non-stick hydrogel dressings were prepared through the simple repeated freeze-thawing of a poly(vinyl alcohol), human-like collagen (or and carboxymethyl chitosan) mixed solution rather than chemical cross-linking and Twe...

Tissue engineering (TE) is an emerging field aimed at repairing defective tissues and organ, instead of relying on conventional organ transplantation. Among the polymeric materials proposed for TE applications, the water-soluble polymers have been frequently used in form of hydrogels, that are a class of highly hydrated polymer materials. Nevertheless, hydrogel materials have poor mechanical pr...

Abstract Using the starting reactants of Zn(OAc) 2 and 2-mercaptonicotinic acid (H L), we successfully synthesized a fresh Zn( ii ) compound, that is, [Zn 3 (L) ] n (1), under hydrothermal conditions then loaded with atenolol. Hualuronic acid/carboxymethyl chitosan hydrogels atenolol drug metal–organic framework were prepared based on chemical synthesis method. The microscopic morphology was in...

The cell wall of most plant biomass from forest and agricultural resources consists of three major polymers, cellulose, hemicellulose, and lignin. Of these, hemicelluloses have gained increasing attention as sustainable raw materials. In this study, novel pH-sensitive semi-IPN hydrogels based on hemicelluloses and chitosan were prepared using glutaraldehyde as the crosslinking agent. The hemice...

In situ gelling constructs, which form a hydrogel at the site of injection, offer the advantage of delivering cells and growth factors to the complex structure of the defect area for tissue engineering. In the present study, visible light crosslinkable hydrogel systems were presented using methacrylated glycol chitosan (MeGC) and three blue light initiators: camphorquinone (CQ), fluorescein (FR...

In most cases, vascularization is the first requirement to achieve tissue regeneration. The delivery from implants of angiogenic factors, like VEGF, has been widely investigated for establishing a vascular network within the developing tissue. In this report, we investigated if encapsulation of VEGF in nanoparticles could enhance angiogenesis in vivo as compared to free VEGF when incorporated i...

The role of Platelet Lysates (PLs) as a source of growth factors (GFs) and as main element of three-dimensional (3D) hydrogels has been previously described. However, the resulting hydrogels usually suffer from high degree of contraction, limiting their usefulness. This work describes the development of a stable biomimetic 3D hydrogel structure based on PLs, through the spontaneous assembling o...

A large number of both natural and synthetic polymers have been studied for powible application in drug delivery. The great advantage of synthetic polymers is their advantageous properties and wide choice availability. Two promising synthetic polymers which have been developed for biomedical applications are polyvinylpyrolidone and polyethylene glycol acrylate based hydrogels. Both of them are ...

Induced biomineralization of materials has been employed as a strategy to increase integration with host tissue, and more recently as a method to control cell function in tissue engineering. However, mineralization is typically performed in the absence of cells, since hypertonic solutions that lack the nutrients and culture components required for the maintenance of cell viability are often use...