Mouse peritoneal macrophages take up acetylated human low density lipoprotein by receptor-mediated endocytosis, hydrolyze its cholesteryl esters in lysosomes, and re-esterify the cholesterol in the cytoplasm. The re-esterified cholesterol accumulates as cytoplasmic lipid droplets that resemble the droplets seen in “foam cells” of atherosclerotic lesions. In the present studies, we have investig...

Cardiovascular diseases, as coronary heart disease, failure, and hypertension are the first leading cause of death in United States third globally. CETP is a glycoprotein excreted mainly from liver found plasma. Normal plasma concentration 1-4 µg/ml, while ratio increased 70-80% dyslipidemic patients. There growing need for new inhibitors which encourages us to conduct this research. In work, s...