objective: a study of the histological events under interleukin-1α (il-lα) induction of bovine nasal cartilage (bnc) could result in useful data to better understand the mechanisms involved in tissue breakdown in joint diseases. the aim of this study was to investigate the effects of il-lα on chondrocyte phenotype and extracellular matrix (ecm) changes in bnc explants. materials and methods: in...

Christian Enrique Garcia Garcia, Frédéric Bossard , Bernard Lardy and Marguerite Rinaudo This paper describes the development of our work on electrospinning chitosan (CS) to get pure nanofiber mats proposed as support for chondrocyte culture.

PURPOSE Some controversy exists regarding the effects of radiofrequency (RF) probes on articular cartilage. To further elucidate these effects, we examined the chondrocyte viability and metabolic activity after treatment of fresh bovine articular cartilage with bipolar RF probes. TYPE OF STUDY In vitro assessment. METHODS Three fresh bovine knees served as a baseline control for chondrocyte...

Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism response to changes in the inflammatory microenvironment may play key role cartilage degeneration OA progression. Under conditions environmental stress, chondrocytes tend adapt their microenvironmental shifting from one metabolic ...

INTRODUCTION: While allogeneic transplantation has attracted much attention in regenerative medicine, animal models approximating safety and efficacy are continued to be explored in translational research because cell sources and transplantation modalities are diverse. Currently, we are preparing for a clinical study using allogeneic chondrocyte sheets for articular cartilage regeneration. In t...