Intravenous vancomycin was approved in 1991 in Japan and has been widely used for treatment of infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Consequently, ever since the initial discovery of vancomycin intermediate-resistant S. aureus in Japan, the vancomycin resistance of this organism has been a great concern in clinical settings. We investigated whether vancomycin ...

Illnesses resulting from antibiotic-resistant bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), are increasing. Recent evidence shows that pathogens once associated with clinical settings are now contaminating non-clinical environments, including public facilities. While methods of isolation and detection of MRSA in clinical settings are established, methods to detect MRSA...

DESIGN Cluster randomised crossover trial with seven wards randomly allocated to intervention or control arm. SETTING Medical and surgical wards of a university hospital with active MRSA control programme. PARTICIPANTS All patients hospitalized >48 h in study wards and screened for MRSA on admission and discharge Intervention: Rapid PCR-based screening test for MRSA compared with control sc...

OBJECTIVES The aim of this study was to assess the in vitro activities of nemonoxacin against Gram-positive cocci with various resistance phenotypes. METHODS MICs of nemonoxacin were determined for 798 recently collected (2005-07) and non-duplicate isolates of Gram-positive cocci by the agar dilution method. These isolates included: methicillin-susceptible Staphylococcus aureus (MSSA; n = 100...

Methicillin-resistant Staphylococcus aureus (MRSA) has a major public health concern. It can be identified throughout the chain of production for poultry, which raises questions regarding potential transmission from farm to consumer. MRSA zoonotic significance and transmitted humans poultry. Several studies have been carried out on but this study was conducted find whole scenario at level. A to...

OBJECTIVES To investigate if colonization with heterogeneous glycopeptide-intermediate Staphylococcus aureus (hGISA) is associated with hGISA bacteraemia. METHODS Isolates of methicillin-resistant S. aureus (MRSA) from blood cultures and from swabs to detect MRSA colonization were screened for reduced susceptibility to glycopeptides by an agar incorporation method. Isolates detected by this s...

Immunodetection of methicillin-resistant Staphylococcus aureus (MRSA) by conventional methods employing mammalian immunoglobulins has unknown detection limits, and often yields false-positive results because of the presence of S. aureus protein A, which binds the Fc region of mammalian IgG. In this study, a new PBP2a-specific chicken IgY antibody was developed in inbred and conventional chicken...

Several studies have been conducted to check the prevalence of methicillin-resistant strains of Staphylococcus aureus (MRSA) in animals and animal-derived food products but limited data are available regarding their virulence and associated gene expression profile. In the present study, antibiotic resistance and virulence of MRSA and methicillin-sensitive S. aureus animal isolates were determin...

Neonates are susceptible to nosocomial infections due to immunological immaturity, prolonged hospital stay and the use of invasive procedures. We evaluated the incidence of infections and the prevalence of colonization by MRSA (Methicillin-resistant Staphylococcus aureus) and MSSA (Methilin-susceptible Staphylococcus aureus), as well as colonization risk factors. Staphylococcal infections were ...

Objective: To determine the prevalence of Methicillin Resistant Staphylococcus aureus (MRSA) in post-operative wound infections in surgical wards and surgical ICU and also to define the antimicrobial susceptibility pattern of the strains isolated. Design: A cross sectional prospective study. Place and Duration of Study: Departments of Pathology and Surgery, Pakistan Institute of Medical Science...