Background: Aberrant chromosomes can cause azoospermia but little is known about its molecular mechanism. Our aim is to explore any possible genetic defective to explain a given male infertility. Materials and Methods: An azoopsermic male was identified in a 23 years old male. G-banding and FISH confirmed the karyotype as chromosome insertion (18:7) (q22.1; q36.2q21.11). NGS was performed to an...

background chromosomal aberrations are one of the most common causes of mental retardation (mr). objectives in this study, in order to identify the rate of chromosomal abnormalities in idiopathic mr, 50 mr patients at a charity center in hamadan, iran, were investigated. methods fifty mentally retarded male patients without specific chromosomal abnormalities (e.g., down syndrome, fragile x synd...

The study of chromosome evolution is undergoing a resurgence interest owing to advances in DNA sequencing technology that facilitate the production chromosome-scale whole-genome assemblies de novo. This review focuses on history, methods, discoveries, and current challenges facing field, with an emphasis vertebrate genomes. A detailed examination literature biology rearrangements presented, spe...

Since the arrival of next-generation sequencing technologies the amount of genetic sequencing data has increased dramatically. This has has fueled an increase in human genetics research. At the same time, with the recent advent of technologies in processing large data sets, lot of these technologies are proving valuable and efficient in analyzing these huge datasets. In this paper we use some o...

Cancer results due to mutations that occur within our genetic material. A small proportion of our genes are directly involved in maintaining normal cell growth; mutations that occur within these genes can eventually lead to cancer. Stevenson et al. was the first to discover the various reasons for the occurrence and the prevalence of cancer with the X-Chromosomal disorders. Our research focused...

conclusions albumin gradient method is the enrichment of y-bearing chromosome sperms. separation of spermatozoa by albumin gradient method, introduced by ericsson, is a suitable method for sex selection of male offspring. this technique is safe, because it neither requires toxic materials during sperm separation, nor involves embryo manipulation. objectives the study aimed to assess the separat...