Hereditary angioedema (HAE) is a rare autosomal dominant disorder caused by reduced activity of the C1 esterase inhibitor. Clinically, angioedema most often involves the upper extremities, face, neck and larynx. The most common cause of death is asphyxia related to laryngeal oedema. Attacks are triggered by many factors such as trauma, stress, infections and hormonal fluctuations. C1 esterase i...

Introducción: El diagnóstico y tratamiento del angioedema hereditario (AEH) son necesarios para mejorar la calidad de vida e incluso supervivencia pacientes. Reporte caso: Mujer 52 años con desde hace 30 años, que afecta cara, lengua manos, asimétrico, sin prurito ni urticaria, respuesta a antihistamínicos corticoides, resolución espontánea entre las 48 72 horas, historia familiar angioedema. E...

Angioedema is a known potential side effect of gabapentin; however, not many reports presentation exist in literature. This report 31-year-old woman who presented with signs sciatica and was started on gabapentin. When the gabapentin dosage increased, she developed angioedema right her face, particularly pronounced periorbital region. Because an acute allergic reaction suspected at first, patie...

progesterone hypersensitivity (ph) is a rare clinical condition that  displays hypersensitivity to  endogenous  or  exogenous progesterone.  it  is characterized by cyclic dermatologic manifestations at the end of the luteal phase that disappear some days after menses. we present  a  case of  24-year-old woman  showing severe angioedema attacks occurring from the first day of her menstruation a...

This guidance for the management of patients with chronic urticaria and angioedema has been prepared by the Standards of Care Committee of the British Society for Allergy and Clinical Immunology (BSACI). The guideline is based on evidence as well as on expert opinion and is aimed at both adult physicians and paediatricians practising in allergy. The recommendations are evidence graded. During t...

Background Angioedema of the upper airway is a life-threatening Emergency Department (ED) presentation with many etiologies. Angiotensin converting enzyme-inhibitor (ACE-I) use is one cause of non-mast cell mediated angioedema. As the use of this medication class increases with our aging population, it is important to characterize the presentation and management of ACE-I induced angioedema (AAE...

Hereditary angioedema (HEA) is a disease characterized by decreased levels or function of C1 esterase inhibitor (C1-INH). The symptoms of HEA in pediatric age group generally consist of recurrent episodes of soft tissue swelling. These symptoms can be transient, subtle, and varied in severity. Genitourinary system is rarely affected in this disease. Here, a three-year-old girl who presented wit...

6. Spaulding WB: Methyltestosterone therapy for hereditary episodic edema (hereditary angioneurotic edema). Ann Intern Med 53:739, 1960 7. Gelfand JA, Sherins RJ, Alling DW, et al: Treatment of hereditary angioedema with danazol. Reversal of clinical and biochemical abnormalities. N Engl J Med 295:1444, 1976 8. Leimbruger A, Jaques WA, Spaeth RJ: Hereditary angioedema uncomplicated maxillofacia...

Angioedema is a potentially life-threatening adverse effect of angiotensin-converting enzyme inhibitors. Bradykinin and substance P, substrates of angiotensin-converting enzyme, increase vascular permeability and cause tissue edema in animals. Studies indicate that amino-terminal degradation of these peptides, by aminopeptidase P and dipeptidyl peptidase IV, may be impaired in individuals with ...

BACKGROUND Hereditary angioedema, a rare and potentially life-threatening condition, is the result of a defect in the C1 esterase inhibitor. Primary care physicians should be familiar with this condition to avoid complications and improve quality of care. METHODS We present two cases of hereditary angioedema followed by a discussion based on a literature review of the recent guidelines and ad...