Abstract: Background: Because neuropathic pain is currently a poorly understood medical condition, there need to identify more effective therapeutic drug with low toxicity profile. Purpose: To address the behavioural, oxidative stress, and cytokine-mediated inflammatory pathways involved in sciatic nerve, current study protocol used Chronic Constriction Injury (CCI) Streptozotocin (STZ) induced...

Neuropathic pain is characterized by hyperalgesia, allodynia and spontaneous pain. Previous studies have shown that Ski-interacting protein (SKIP) played an important role in neuronal survival and neuroprotection. However, its expression and function in neuropathic pain remains unknown. We found that the level of SKIP was increased in the spinal cord in a time dependent manner after chronic con...

........................................................................................................4 Introduction.....................................................................................................5 Methods.........................................................................................................7 Somatosensory Evoked Potential Mapping...........................

Investigators model noncardiogenic pulmonary hypertension by constricting the pulmonary artery to increase right ventricular afterload. To investigate this model's validity, we compared the right ventricular afterload, quantified as pulmonary input impedance, created by constricting the pulmonary artery and by inducing a pulmonary microvascular injury (with glass beads infused into the pulmonar...

Introduction: Pharmacological blockage of glial activity has been proved useful for treatment of neuropathic pain by lowering proinflammatory cytokines. The present study is to confirm the effect of post-injury administration of pentoxifylline on chronic constriction injury (CCI)-induced neuropathic pain symptoms_ and improved the efficacy of morphine anti-nociception. Methods: Male Wistar ...

Although activated spinal cord glia contribute importantly to neuropathic pain, how nerve injury activates glia remains controversial. It has recently been proposed, on the basis of genetic approaches, that toll-like receptor 4 (TLR4) may be a key receptor for initiating microglial activation following L5 spinal nerve injury. The present studies extend this idea pharmacologically by showing tha...

Opioid use for pain management has dramatically increased, with little assessment of potential pathophysiological consequences for the primary pain condition. Here, a short course of morphine, starting 10 d after injury in male rats, paradoxically and remarkably doubled the duration of chronic constriction injury (CCI)-allodynia, months after morphine ceased. No such effect of opioids on neurop...