Chrysin is a naturally occurring bioflavonoid found in honey and propolis, with anti-cancer anti-inflammatory properties. This study aimed to investigate the therapeutic effect of chrysin combined 5-fluorouracil (5-FU) treatment mice colorectal cancer (CRC). Moreover, effects these two compounds on expression β-catenin inducible nitric oxide synthase (iNOS) were investigated. The CRC was induce...

Christia vespertilionis (L.f.) Bakh. f. is an ornamental plant with unique butterfly-shaped leaves, hence its vernacular name “butterfly wing” or “rerama” in Malay. In Malaysia, the green-leafed variety of this has gained popularity recent years due to testimonial reports by local consumers medicinal uses, which include treatment for cancer. Despite these popular there very limited information ...

Targeted activation of pregnane X receptor (PXR) in recent years has become a therapeutic strategy for inflammatory bowel disease. Chrysin is a naturally occurring flavonoid with antiinflammation activity. The current study investigated the role of chrysin as a putative mouse PXR agonist in preventing experimental colitis. Pre-administration of chrysin ameliorated inflammatory symptoms in mouse...

Rhagadiolus stellatus Gaertn., a Mediterranean member of the Cichorieae tribe of the Asteraceae family used as a food plant, was analyzed for its spectrum of phenolic compounds. Kaempferol 3-O-β-glucoside 1, kaempferol 3-O-β-rutinoside (nicotiflorin) 2, quercetin 3-O-β-glucoside 3, and luteolin 4 were isolated from the n-butanol layer of a methanolic extract of whole plants of Rh. stellatus of ...

In addition to benjaminamide (2), β-amyrin, β-amyrin acetate, lupeol, betulinic acid, β-sitosterol glucoside, a new ceramide glycoside was isolated from the woods of Ficus lutea Vahl (Moraceae). Using mass fragmentation pattern, 1 and 2D NMR spectra and by comparison with published data, the new compound was characterized as 1-O-β-D-glucopyranosyl-(2S,3R,5E,12E)-2N-[(2'R)-hydroxyhexadecanoyl]-o...

In Mexico Agave angustifolia has traditionally been used to treat inflammation. The aim of this study was to measure the anti-inflammatory effect of the extract of A. angustifolia, the isolation and identification of active compounds. From the acetone extract two active fractions were obtained, (AsF13 and AaF16). For the characterization of pharmacological activity, the acute inflammatory model...

Adhesion of leukocytes to endothelial cells plays an important role in neuroinflammation. Therefore, suppression of the expression of adhesion molecules in brain endothelial cells may inhibit neuroinflammation. Chrysin (5,7-dihydroxyflavone) is a flavonoid component of propolis, blue passion flowers, and fruits. In the present study, we examined the effects of chrysin on lipopolysaccharide (LPS...

In this Note we study the causal (anticausal) generalized Riesz potential of order α:R Cf(R α A)f) of the function f∈S (cf. (I,1;8) and (I,1;9), respectively). The distributional functions R Cf(R α Af) are causal (anticausal) analogues of the α -dimensional potentials in the ultrahyperbolic space defined by Nozaki (cf. [6], p.85). Therefore, we define the generalized causal (anticausal) Riesz d...