By modeling the statistical evolution of an avalanche created by 20 keV protons impacting the input surface of a z-stack microchannel plate ~MCP! detector, the mean secondary electron yield gC of avalanche electrons propagating through a MCP channel is measured to equal 1.37 for 760 V per MCP in the z stack. This value agrees with other studies that used MCP gain measurements to infer gC . The ...

A non destructive low intensity ion beam profile monitor has been designed and tested. The system is based on a MCP that detects the residual gas ionization produced by the ion beam. The detector is coupled to a phosphorous screen for the readout of the vertical and horizontal density profiles. Experimental results have shown that the system is able to detect beam intensities as low as 10 pps w...

This paper presents a hybrid manufacturing process for the preparation of complex cavity structure parts with high surface quality. Firstly, laser precision packaging technology is utilized to accurately connect thin plate substrate microchannel. Secondly, Direct Metal Laser-Sintering (DMLS) completely shape part. The morphology and microstructure encapsulated specimens DMLS molded were investi...

Portable electronic devices such as notebook computers, PDAs, cellular phones, etc., are being widely used, and they increasingly need cheap, efficient, and lightweight power sources. Fuel cells have been proposed as possible power sources to address issues that involve energy production and the environment. In particular, a small type of fuel-cell system is known to be suitable for portable el...

We have developed a novel microchannel plate readout scheme, the cross strip anode. The cross strip anode has a coarse (0.5mm) multilayer metal and ceramic cross strip pattern that encodes event positions by direct sensing of the charge on each strip and subsequent determination of the charge cloud centroid for each event. Event position encoding is accomplished with chip level preamplifiers on...

BACKGROUND Genetic analysis of microsatellite DNA is a powerful tool used in linkage analysis, gene mapping, and clinical diagnosis. To address the expanding needs of studies of short tandem repeats (STRs), we demonstrated high-performance STR analysis on a high-throughput microchannel plate-based platform. METHODS Energy-transfer-cassette-labeled STR amplicons were separated and typed on a m...

This paper presents a simple fluid handling technique for microchip immunoassay. Necessary solutions were sequentially injected into a microchannel by air-evacuated poly(dimethylsiloxane), and were passively regulated by capillary force at the inlet opening. For heterogeneous immunoassay, microchips are potentially useful for reduction of sample consumption and assay time. However, most of the ...

The compatibility of polydimethylsiloxane (PDMS) channels with certain solvents is a well known problem of soft lithography techniques, in particular when it leads to the swelling of the PDMS blocks. However, little is known about the modification of microchannel geometries when they are subjected to swelling solvents. Here, we experimentally measure the deformations of the roof of PDMS microch...

The diffusion phenomena, dispersion and mixing processes of the sample solute (Basic Blue 3 dye and KMnO4 aqueous solutions) were directly observed in laminar flow in glass microchannels. Quasi steady-state UV-visible absorption spectrometry was carried out using CCD camera images of the colored sample dispersion and mixing processes, and the absorbance change (DeltaAbs) was discussed based on ...

In this work we report on a simple inertial microfluidic device that achieves continuous multi-particle separation using the principle of Dean-coupled inertial migration in spiral microchannels. The dominant inertial forces coupled with the Dean rotational force due to the curvilinear microchannel geometry cause particles to occupy a single equilibrium position near the inner microchannel wall....