Selective renal medullary destruction is produced in rats by a single injection of 2-bromoethylamine hydrobromide. The object of these studies was to investigate whether destruction of the renal medulla in normal rats would alter vascular capacitance. Conscious bromoethylamine-treated rats (n = 15) were compared with control saline-injected rats (n = 12). Mean circulatory filling pressure was m...

The total blood flow requirements of a large muscle mass can exceed the maximal cardiac output generated by the heart during exercise. Therefore, to maintain blood pressure, muscle vasodilation must be opposed by sympathetic vasoconstriction. The primary neural signal that increases sympathetic outflow is unclear. In an effort to isolate the vasoconstricting mechanism that opposes vasodilation,...

BACKGROUND This study was undertaken to define the factors that influence mortality rate and neurologic outcome after repair of the aortic arch and various portions of the thoracic aorta in patients with profound hypothermia and circulatory arrest. METHODS Between November 1986 and January 1996, 105 patients were treated surgically for aortic disease involving the transverse aortic arch. Prof...

PURPOSE To determine the timing of spontaneous venous pulsation (SVP) relative to the ocular circulatory cycle by using the movie tool of confocal scanning laser ophthalmoloscope. METHODS A video recording of the fundus was obtained using a confocal scanning laser ophthalmoscope (Spectralis HRA, Heidelberg Engineering, Heidelberg, Germany) at 8 frames/s in 47 eyes (15 glaucoma patients and 32...

According to the World Health Organization’s data, circulatory diseases are the world's leading cause of death, being responsible for the death of 17 million people annually, 5,5 million of them being in Europe. According to the data of the Croatian National Institute of Public Health, circulatory diseases are the leading cause of death in Croatia as well. In the year 2005, there were 26,029 re...

The Pediatric Circulatory Support Program (PCSP) of the National Heart, Lung, and Blood Institute (NHLBI) was established to fund the development of novel circulatory support devices for children with medically refractory heart failure.1 Before this, developers of circulatory support devices found little incentive to enter the pediatric market because of the small patient numbers that are gener...

Percutaneous mechanical circulatory support has been used to stabilize patients in cardiogenic shock and provide hemodynamic support during high-risk percutaneous coronary interventions for several decades. The goal of this paper is to provide a practical approach to percutaneous mechanical circulatory support in patients undergoing percutaneous coronary intervention with cardiogenic shock and/...

Introduction Recently the indication of extracorporeal membrane oxygenation (ECMO) treatment has been expanded to various diseases with circulatory and respiratory failure and the duration of ECMO management tend to be longer due to the development of related device. In some cases with long run of ECMO, the conversion of ECMO needs to be considered depending on the respiratory and circulatory s...

We developed an experimental method which enabled continuous determination of the circulatory blood volume, when the blood volume was subjected to alterations. The blood volume was modified by a servo system to control transfer of the blood between an external reservoir and the cardiovascular system. Possible application of our method to the analysis of circulatory responses to blood volume cha...

This essay examines the historical significance of an APS classic paper that is freely available online: Guyton AC, Lindsey AW, and Kaufmann BN. Effect of mean circulatory filling pressure and other peripheral circulatory factors on cardiac output. Am J Physiol 180: 463-468, 1955 (http://ajplegacy.physiology.org/cgi/reprint/180/3/463).